Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

When fully extended, one copy of the three billion base pair human genome reaches a
length of over two meters. Yet, it must be packaged into the nucleus of a cell with an average …

Chromatin compacts genomic DNA in eukaryotes. The primary chromatin unit is the
nucleosome core particle, composed of four pairs of the core histones, H2A, H2B, H3, and …

Histone replacement by transition proteins (TPs) and protamines (Prms) constitutes an
essential step for the successful production of functional male gametes, yet nothing is known …

Chromatin is a dynamic molecular complex composed of DNA and proteins that package the
DNA in the nucleus of eukaryotic cells. The basic structural unit of chromatin is the …

In eukaryotes, genomic DNA is compacted in chromatin, which generally suppresses
transcription, replication, repair, and recombination. The fundamental unit of chromatin is the …

In eukaryotes, variants of core histone H2A are selectively incorporated in distinct functional
domains of chromatin and are distinguished by conserved sequences of their C-terminal tail …

The structure and dynamics of promoter chromatin have a profound effect on the expression
levels of genes. Yet, the contribution of DNA sequence, histone post-translational …

Trypanosomes diverged from the main eukaryotic lineage about 600 million years ago, and
display some unusual genomic and epigenetic properties that provide valuable insight into …

The eukaryotic nucleosome prevents access to the genome. Convergently evolving histone
isoforms, also called histone variants, form diverse families that are enriched over distinct …