Zinc finger proteins in neuro-related diseases progression

S Bu, Y Lv, Y Liu, S Qiao, H Wang - Frontiers in neuroscience, 2021 - frontiersin.org
Zinc finger proteins (ZNF) are among the most abundant proteins in eukaryotic genomes. It
contains several zinc finger domains that can selectively bind to certain DNA or RNA and …

New approaches to target RNA binding proteins

AR Julio, KM Backus - Current opinion in chemical biology, 2021 - Elsevier
RNA binding proteins (RBPs) are a large and diverse class of proteins that regulate all
aspects of RNA biology. As RBP dysregulation has been implicated in a number of human …

Small molecule targeting CELF1 RNA-binding activity to control HSC activation and liver fibrosis

Y Tan, X Sun, Y Xu, B Tang, S Xu, D Lu… - Nucleic Acids …, 2022 - academic.oup.com
CUGBP Elav-like family member 1 (CELF1), an RNA-binding protein (RBP), plays important
roles in the pathogenesis of diseases such as myotonic dystrophy, liver fibrosis and cancers …

Controversial roles of cold‑inducible RNA‑binding protein in human cancer

YM Kim, S Hong - International Journal of Oncology, 2021 - spandidos-publications.com
Cold‑inducible RNA‑binding protein (CIRBP) is a cold‑shock protein comprised of an RNA‑
binding motif that is induced by several stressors, such as cold shock, UV radiation, nutrient …

Small molecule inhibition of RNA binding proteins in haematologic cancer

AK Jaiswal, ML Thaxton, GM Scherer, JP Sorrentino… - RNA biology, 2024 - Taylor & Francis
In recent years, advances in biomedicine have revealed an important role for post-
transcriptional mechanisms of gene expression regulation in pathologic conditions. In …

Screening Techniques for Drug Discovery in Alzheimer's Disease

S Maniam, S Maniam - ACS omega, 2024 - ACS Publications
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive and
irreversible impairment of memory and other cognitive functions of the aging brain …

Analysis of ROQUIN, Tristetraprolin (TTP), and BDNF/miR-16/TTP regulatory axis in late onset Alzheimer's disease

MR Asadi, M Talebi, J Gharesouran… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a heterogeneous degenerative disorder of the brain that is on
the rise worldwide. One of the critical processes that might be disturbed in AD is gene …

Endoplasmic reticulum unfolded protein response transcriptional targets of XBP-1s mediate rescue from tauopathy

SM Waldherr, M Han, AD Saxton, TA Vadset… - Communications …, 2024 - nature.com
Pathological tau disrupts protein homeostasis (proteostasis) within neurons in Alzheimer's
disease (AD) and related disorders. We previously showed constitutive activation of the …

Selective neuronal vulnerability to deficits in RNA processing

G Zuniga, B Frost - Progress in Neurobiology, 2023 - Elsevier
Emerging evidence indicates that errors in RNA processing can causally drive
neurodegeneration. Given that RNA produced from expressed genes of all cell types …

An insight into structure-activity relationship of naturally derived biological macromolecules for the treatment of Alzheimer's disease: a review

D Halder, S Das, A Joseph - Journal of Biomolecular Structure and …, 2024 - Taylor & Francis
Alzheimer's disease (AD) is a neurological disorder that affects millions of people worldwide.
There are currently no cures for AD, although various drugs are used to manage the …