▪ Abstract In the absence of antiretroviral treatment, HIV-1 establishes a chronic, progressive
infection of the human immune system that invariably, over the course of years, leads to its …

T cell reconstitution following lymphopenia from chemotherapy or stem cell transplant is
often slow and incompetent, contributing to the development of infectious diseases, relapse …

Delayed T cell recovery and restricted T cell receptor (TCR) diversity after allogeneic
hematopoietic stem cell transplantation (allo-HSCT) are associated with increased risks of …

Homeostatic regulation of T cells involves an ongoing balance of new T cell generation,
peripheral expansion, and turnover. The recovery of T cells when this balance is disrupted …

Advances in immune assessment, including the development of T-cell receptor excision
circle (TREC) assays of thymopoiesis, cytokine-flow cytometry assays of T-cell function, and …

Hematopoietic cell transplantation (HCT) can be curative for selected malignant and
nonmalignant diseases. 1-13 However, utilization and success of HCT are limited by several …

The generation of the TCRαβ lineage of T cells occurs in the thymus through a series of
orchestrated developmental events that result in a carefully selected population of CD4 or …

Thymic activation improves the outcome of COVID-19 patients with severe pneumonia. The
rs2204985 genetic polymorphism within the TCRA-TCRD locus, which affects thymic output …

In vivo T-cell depletion might contribute to the delayed immune reconstitution observed after
unrelated umbilical cord blood transplantation (UCBT). We studied the impact of early, late …

Aging is associated clinically with increases in the frequency and severity of infectious
diseases and an increased incidence of cancer, chronic inflammatory disorders and …