The success of cancer immunotherapy relies on the knowledge of the tumor
microenvironment and the immune evasion mechanisms in which the tumor, stroma, and …

Abstract Treatment of high-grade serous ovarian cancer (HGSOC) remains challenging.
Although HGSOC can potentially be responsive to immunotherapy owing to endogenous …

The mechanisms regulating exhaustion of tumor-infiltrating lymphocytes (TIL) and
responsiveness to PD-1 blockade remain partly unknown. In human ovarian cancer, we …

The CD40 receptor and its ligand CD40L is one of the most critical molecular pairs of the
stimulatory immune checkpoints. Both CD40 and CD40L have a membrane form and a …

Highlights•Oncolytic viruses (OVs) can modulate tumour microenvironment (TME) towards
less immunosuppressive phenotype and induce anti-cancer immunity.•OVs can be used as …

The substantial advances attained by checkpoint blockade immunotherapies have driven an
expansion in the approaches used to promote T cell access to the tumor microenvironment …

Myeloid-derived suppressor cells (MDSCs) are heterogeneous and poorly mature cells of
innate immunity that their population is increased substantially in cancer patients. MDSCs …

Immune-inflammatory conditions in the central nervous system (CNS) rely on molecular and
cellular interactions which are homeostatically maintained to protect neural tissue from …

Immunogenic cell death (ICD) is one of the 12 distinct cell death forms, which can trigger
immune system to fight against cancer cells. During ICD, a number of cellular changes occur …

ABSTRACT TNF Receptor Superfamily (TNF-R-SF) signaling is a structurally well-defined
event that requires proper receptor clustering and trimerization. While the TNF-SF ligands …