Cell-replacement therapies have long been an attractive prospect for treating Parkinson
disease. However, the outcomes of fetal tissue-derived cell transplants in individuals with …

In the long-term, with progression of the illness, Parkinson's disease dementia affects up to
90% of patients with Parkinson's disease. With increasing life expectancy in western …

Two subjects with Parkinson's disease who had long-term survival of transplanted fetal
mesencephalic dopaminergic neurons (11–16 years) developed α-synuclein–positive Lewy …

Thirty‐four patients with advanced Parkinson's disease participated in a prospective 24‐
month double‐blind, placebo‐controlled trial of fetal nigral transplantation. Patients were …

Clinical use of allografts of fetal ventral mesencephalic tissue as a treatment to replace
dopaminergic neurons in patients with Parkinson's disease was first done more than 20 …

Importance Recent advances in stem cell technologies have rekindled an interest in the use
of cell replacement strategies for patients with Parkinson disease. This study reports the very …

Human neurological disorders such as Parkinson's disease, Huntington's disease,
amyotrophic lateral sclerosis (ALS), Alzheimer's disease, multiple sclerosis (MS), stroke, and …

Troublesome involuntary movements in the absence of dopaminergic medication, so-called
off-medication dyskinesias, are a serious adverse effect of fetal neural grafts that hinders the …

We report the first post-mortem analysis of two patients with Parkinson's disease who
received fetal midbrain transplants as a cell suspension in the striatum, and in one case also …

Neuropathological changes in Parkinson's disease progress slowly and spread according to
a characteristic pattern. Recent papers have shed light on this progression of pathology by …