Huntington's disease is a severe and currently incurable neurodegenerative disease. An
autosomal dominant mutation in the Huntingtin gene (HTT) causes an increase in the …

Microglia reactivity entails a large-scale remodeling of cellular geometry, but the behavior of
the microtubule cytoskeleton during these changes remains unexplored. Here we show that …

The fine control of inflammation following injury avoids fibrotic scars or impaired wounds.
Due to side effects by anti-inflammatory drugs, the research is continuously active to define …

Histone deacetylases (HDACs) are a group of enzymes that remove acetyl groups from
histones, leading to the silencing of genes. Targeting specific isoforms of HDACs has …

Microglia reactivity triggered by proinflammatory signaling entails a large-scale remodeling
of cellular geometry, but the role of the microtubule cytoskeleton during these changes …

Microglia are the resident immune cells of the brain, crucial for the maintenance of the
homeostasis in the central nervous system. They are responsible for removing cellular …

Background The polarized migratory microglia consisting of front edge lamellipodia and rear
edge uropod direct migration at the chemotactic gradient. Thus, maintenance of polarized …