Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …

Microglia are emerging as key players in neurodegenerative diseases, such as Alzheimer's
disease (AD). Thus far, microglia have rather been known as modulator of …

Alzheimer's disease (AD) is the most common type of senile dementia, characterized by
neurofibrillary tangle and amyloid plaque in brain pathology. Major efforts in AD drug were …

An unexpected role for the classical complement cascade in the elimination of central
nervous system (CNS) synapses has recently been discovered. Complement proteins are …

β‐amyloid (Aβ) is widely accepted to be one of the major pathomechanisms underlying
Alzheimer's disease (AD), although there is presently lively debate regarding the relative …

Compelling preclinical and clinical evidence supports a pathophysiological connection
between Alzheimer's disease (AD) and diabetes. Altered metabolism, inflammation, and …

Extracellular plaques of amyloid-β and intraneuronal neurofibrillary tangles made from tau
are the histopathological signatures of Alzheimer's disease. Plaques comprise amyloid-β …

The production of soluble amyloid-β oligomers (AβOs) and the activation of inflammation are
two important early steps in the pathogenesis of Alzheimer's disease (AD). The central role …

J. Neurochem.(2012) 120 (Suppl. 1), 125–139. Abstract For nearly 100 years following the
first description of this neurological disorder by Dr Alois Alzheimer, amyloid plaques and …

Mushroom dendritic spine structures are essential for memory storage, and the loss of
mushroom spines may explain memory defects in Alzheimer's disease (AD). Here we show …