The ζ isotype of protein kinase C (PKCζ) is a member of the atypical PKC subfamily and has
been widely implicated in the regulation of cellular functions. Increasing evidence from …

Squamous cell carcinoma (SCC) of the human esophagus has a multifactorial etiology
involving several environmental and/or genetic factors. Current modalities of therapy for this …

While genetic mutation is a hallmark of cancer, many cancers also acquire epigenetic
alterations during tumorigenesis including aberrant DNA hypermethylation of tumor …

2014-11-12 Assigned to IMMATICS BIOTECHNOLOGIES GMBH reassignment IMMATICS
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

Deletions of chromosome 8p are a recurrent event in B-cell non-Hodgkin lymphoma (B-
NHL), suggesting the presence of a tumor suppressor gene. We have characterized these …

Chromosomal deletion appears to be the earliest as well as the most frequent somatic
genetic alteration during carcinogenesis. It inactivates a tumor suppressor gene in three …

Molecular markers have the potential to serve not only as prognostic factors but may be
targets for new therapeutic strategies and predictors of response in a range of cancers …

Esophageal squamous cell carcinoma (ESCC) is a frequent form of cancer that shows
striking variations in geographic distribution, reflecting exposure to specific environmental …

Promoter hypermethylation is an alternative way to inactivate tumor suppressor genes in
cancer. Alterations of chromosome 3p are frequently involved in many types of cancer …

Despite the high incidence of prostate cancer, only limited data are available on genes or
chromosomes specifically involved in its initiation and progression. We have applied …