Alzheimer's disease (AD) is the most common form of dementia worldwide, with a complex,
poorly understood pathogenesis. Cerebral atrophy, amyloid-β (Aβ) plaques, and …

A cell is delimited by numerous borders that define specific organelles. The walls of some
organelles are particularly robust, such as in mitochondria or endoplasmic reticulum, but …

The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT).
Indeed, specific lipids can harm CD8+ T cell (CTL) mitochondrial integrity, leading to …

Ions play a vital role in regulating various biological processes, including metabolic and
immune homeostasis, which involves tumorigenesis and therapy. Thus, the perturbation of …

Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder that
is characterized by amyloid β-protein deposition in senile plaques, neurofibrillary tangles …

Perturbation of endoplasmic reticulum (ER) homeostasis results in a stress condition termed
“ER stress” determining the activation of a finely regulated program defined as unfolded …

Parkinson's disease (PD) is a chronic and progressive neurodegeneration of dopamine
neurons in the substantia nigra. The reason for the death of these neurons is unclear; …

Lipid droplet (LD) accumulation is a now well-recognised hallmark of cancer. However, the
significance of LD accumulation in colorectal cancer (CRC) biology is incompletely …

Evidence suggests that caffeine (CF) reduces cardiovascular disease (CVD) risk. However,
the mechanism by which this occurs has not yet been uncovered. Here, we investigated the …

Besides their main function for energy production in form of ATP in processes of oxidative
phosphorylation (OxPhos), mitochondria perform many other important cellular functions …