Phase separation and pathologic transitions of RNP condensates in neurons: implications for amyotrophic lateral sclerosis, frontotemporal dementia and other …

A Naskar, A Nayak, MR Salaikumaran… - Frontiers in Molecular …, 2023 - frontiersin.org
Liquid–liquid phase separation results in the formation of dynamic biomolecular
condensates, also known as membrane-less organelles, that allow for the assembly of …

Pathological phase transitions in ALS-FTD impair dynamic RNA–protein granules

NB Nedelsky, JP Taylor - Rna, 2022 - rnajournal.cshlp.org
The genetics of human disease serves as a robust and unbiased source of insight into
human biology, both revealing fundamental cellular processes and exposing the …

The fission yeast cell integrity pathway: a functional hub for cell survival upon stress and beyond

J Cansado, T Soto, A Franco, J Vicente-Soler… - Journal of Fungi, 2021 - mdpi.com
The survival of eukaryotic organisms during environmental changes is largely dependent on
the adaptive responses elicited by signal transduction cascades, including those regulated …

Post-transcriptional regulation during stress

M Hernández-Elvira, P Sunnerhagen - FEMS Yeast Research, 2022 - academic.oup.com
To remain competitive, cells exposed to stress of varying duration, rapidity of onset, and
intensity, have to balance their expenditure on growth and proliferation versus stress …

A dynamic actin cytoskeleton is required to prevent constitutive VDAC-dependent MAPK signalling and aberrant lipid homeostasis

J Davis, T Meyer, M Smolnig, DGJ Smethurst… - Iscience, 2023 - cell.com
The dynamic nature of the actin cytoskeleton is required to coordinate many cellular
processes, and a loss of its plasticity has been linked to accelerated cell aging and …

The role of stress-activated RNA–protein granules in surviving adversity

LE Escalante, AP Gasch - RNA, 2021 - rnajournal.cshlp.org
Severe environmental stress can trigger a plethora of physiological changes and, in the
process, significant cytoplasmic reorganization. Stress-activated RNA–protein granules …

Lipid‐lowering activity and underlying mechanism of glycosylated peptide–calcium chelate prepared by transglutaminase pathway

X Wu, X Chen, X Cai, S Wang - Food Frontiers, 2024 - Wiley Online Library
The compounds that promote calcium absorption and osteogenesis may have great
potential in controlling adipogenesis and obesity. In this study, the glycosylated peptides …

[HTML][HTML] Sequestration of cellular native factors by biomolecular assemblies: Physiological or pathological?

HY Hu, YJ Liu - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2022 - Elsevier
In addition to native-state structures, biomolecules often form condensed supramolecular
assemblies or cellular membraneless organelles that are critical for cell life. These …

[HTML][HTML] Atg1, a key regulator of autophagy, functions to promote MAPK activation and cell death upon calcium overload in fission yeast

T Takasaki, R Utsumi, E Shimada, A Bamba… - Microbial Cell, 2023 - ncbi.nlm.nih.gov
Autophagy promotes or inhibits cell death depending on the environment and cell type. Our
previous findings suggested that Atg1 is genetically involved in the regulation of Pmk1 …

Arsenite treatment induces Hsp90 aggregatesdistinct from conventional stress granules in fission yeast

N Tomimoto, T Takasaki, R Sugiura - Microbial Cell, 2024 - pmc.ncbi.nlm.nih.gov
Various stress conditions, such as heat stress (HS) and oxidative stress, can cause
biomolecular condensates represented by stress granules (SGs) via liquid-liquid phase …