Throughout the nervous system, moment-to-moment communication relies on postsynaptic
receptors to detect neurotransmitters and change the membrane potential. For the Cys-loop …

This is an electronic copy of the Plymouth Workshop Handbook reproduced with permission
from the Company of Biologists (www. biologists. com). The Handbook accompanies the …

The discovery of artemisinin more than 30 years ago provided a completely new antimalarial
structural prototype; that is, a molecule with a pharmacophoric peroxide bond in a unique 1 …

With prolonged stimulation, voltage-activated K+ channels close by a gating process called
inactivation. This inactivation gating can occur by two distinct molecular mechanisms: N …

AMPA receptor GluRA subunits with mutations at position 750, a residue shown previously
to control allosteric regulation by cyclothiazide, were analyzed for modulation of deactivation …

Excised outside‐out patches from HEK293 cells stably transfected with the human (h) 5‐
HT3A receptor cDNA were used to determine the effects of cannabinoid receptor ligands on …

Neurotransmitter receptors from the Cys-loop superfamily couple the binding of agonist to
the opening of an intrinsic ion pore in the final step in rapid synaptic transmission. Although …

In the course of synaptic transmission in the brain and periphery, acetylcholine receptors
(AChRs) rapidly transduce a chemical signal into an electrical impulse. The speed of …

In five members of a family and another unrelated person affected by a slow-channel
congenital myasthenic syndrome (SCCMS), molecular genetic analysis of acetylcholine …

We have examined CABA* receptor activation by making rapid applications of GABA to
outside-out patches excised from cultured postnatal rat cerebellar neurons. The rate of …