Acid‐sensing ion channels (ASICs) are a class of trimeric cation‐selective ion channels
activated by changes in pH within the physiological range. They are widely expressed in the …

Routine physical activity reduces the onset of pain and exercise is a first line treatment for
individuals who develop chronic pain. In both preclinical and clinical research regular …

Tactile discrimination, the ability to differentiate objects' physical properties such as texture,
shape, and edges, is essential for environmental exploration, social interaction, and early …

As a reversible scar repair reaction, liver fibrosis can be blocked or even reversed by proper
intervention during its formation. Our work suggests that acid‐sensitive ion channel 1a …

Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels
largely expressed in the nervous system of rodents and humans. At least six isoforms …

Acid-sensing ion channels (ASICs) are proton-gated, voltage-independent sodium channels
widely expressed throughout the central and peripheral nervous systems. They are involved …

Sensing acidosis is an important somatosensory function in responses to ischemia,
inflammation, and metabolic alteration. Accumulating evidence has shown that acidosis is …

Acid-sensing ion channels (ASICs) are cation-permeable channels that in the periphery are
primarily expressed in sensory neurons that innervate tissues and organs. Soon after the …

We developed an animal model of activity-induced muscle pain that is dependent on local
macrophage activation and release of interleukin-1b (IL-1b). Activation of purinergic type 2X …

Activity-induced pain is common in those with chronic musculoskeletal pain and limits
participation in daily activities and exercise. Our laboratory developed a model of activity …