The genetics of portal hypertension: Recent developments and the road ahead

S Shalaby, L Ronzoni, V Hernandez‐Gea… - Liver …, 2023 - Wiley Online Library
Portal hypertension (PH), defined as a pathological increase in the portal vein pressure, has
different aetiologies and causes. Intrahepatic PH is mostly secondary to the presence of …

Genetic predisposition to porto-sinusoidal vascular disorder

N Ciriaci, L Bertin, PE Rautou - Hepatology, 2024 - journals.lww.com
Porto-sinusoidal vascular disorder is a rare liver disease. The pathophysiological
mechanisms underlying the development of porto-sinusoidal vascular disorder are …

Molecular Mechanisms Underlying Vascular Liver Diseases: Focus on Thrombosis

L Giuli, M Pallozzi, G Venturini, A Gasbarrini… - International Journal of …, 2023 - mdpi.com
Vascular liver disorders (VLDs) comprise a wide spectrum of clinical-pathological entities
that primarily affect the hepatic vascular system of both cirrhotic and non-cirrhotic patients …

[HTML][HTML] Genetics of liver disease in adults

C Konkwo, S Chowdhury… - Hepatology …, 2024 - journals.lww.com
Chronic liver disease stands as a significant global health problem with an estimated 2
million annual deaths across the globe. Combining the use of next-generation sequencing …

[HTML][HTML] High prevalence of short telomeres in idiopathic porto-sinusoidal vascular disorder

A Coukos, C Saglietti, C Sempoux… - Hepatology …, 2024 - journals.lww.com
Background: Telomeres prevent damage to coding DNA as end-nucleotides are lost during
mitosis. Mutations in telomere maintenance genes cause excessive telomere shortening, a …

Elevated Hepatic Copper Content in Porto‐Sinusoidal Vascular Disorder (PSVD): Leading Down a Wrong Track

L Balcar, N Dominik, B Mozayani, G Semmler… - Liver …, 2025 - Wiley Online Library
ABSTRACT Background and Aims Porto‐sinusoidal vascular disorder (PSVD) is a rare
vascular liver disorder characterised by specific histological findings in the absence of …

[HTML][HTML] Metabolomic profiles differentiate between porto-sinusoidal vascular disorder, cirrhosis, and healthy individuals

G Semmler, O Petrenko, JJ Lozano, S Shalaby… - JHEP Reports, 2024 - Elsevier
Background & Aims Porto-sinusoidal vascular disorder (PSVD) is a rare and diagnostically
challenging vascular liver disease. This study aimed to identify distinct metabolomic …

Genomic profile of Parkinson's disease in Asians

V Besin, FM Humardani, T Yulianti, M Justyn - Clinica Chimica Acta, 2024 - Elsevier
Parkinson's Disease (PD) has witnessed an alarming rise in prevalence, highlighting the
suboptimal nature of early diagnostic and therapeutic strategies. To address this issue …

[HTML][HTML] Portal hypertension: recommendations for diagnosis and treatment. Consensus document sponsored by the Spanish Association for the Study of the Liver …

A Albillos, R Bañares, V Hernández-Gea… - … y Hepatología (English …, 2025 - Elsevier
Portal hypertension is a hemodynamic abnormality that complicates the course of cirrhosis,
as well as other diseases that affect the portal venous circulation. The development of portal …

Porto-sinusoidal vascular disease: a new definition of an old clinical entity

M Barisic-Jaman, M Milosevic, F Pastrovic… - Clinical and …, 2023 - termedia.pl
Porto-sinusoidal vascular disease (PSVD) is defined as a vascular liver disease
characterized by the absence of cirrhosis and the presence of characteristic histological …