In this review, we discuss recent advances made on histone methylation and its diverse
functions in regulating gene expression. Methylation of histone polypeptides might be static …

Drug resistance remains a major challenge in cancer treatment, necessitating the
development of novel strategies to overcome it. Protein arginine methyltransferases …

A Drosophila homolog of human Down syndrome cell adhesion molecule (DSCAM), an
immunoglobulin superfamily member, was isolated by its affinity to Dock, an SH3/SH2 …

Protein methylation is a stable post-translational modification (PTM) with important biological
functions. It occurs predominantly on arginine and lysine residues with varying numbers of …

We have identified a new mammalian protein arginine N-methyltransferase, PRMT5,
formerly designated Janus kinase-binding protein 1, that can catalyze the formation of ω-N G …

Posttranslational modifications of histone amino termini play an important role in modulating
chromatin structure and function [1–3]. Lysine methylation of histones has been well …

PRMT1 is the predominant type I protein arginine methyltransferase in mammals and highly
conserved among all eukaryotes. It is essential for early postimplantation development in …

The treatment of cancer through the development of new therapies is one of the most
important challenges of our time. The decoding of the human genome has yielded important …

▪ Abstract With genome sequencing nearing completion for the model organisms used in
biomedical research, there is a rapidly growing appreciation that proteomics, the study of …

Protein arginine methylation is a prevalent posttranslational modification in eukaryotic cells
that has been implicated in signal transduction, the metabolism of nascent pre-RNA, and the …