Alzheimer's disease (AD) is the major cause of dementia in Western societies. It progresses
asymptomatically during decades before being belatedly diagnosed when therapeutic …

Metabolic rewiring is often considered an adaptive pressure limiting metastasis formation;
however, some nutrients available at distant organs may inherently promote metastatic …

Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

The prefrontal cortex (PFC) is a key region implicated in a range of neuropsychiatric
disorders such as depression, schizophrenia and autism. In parallel, the role of the gut …

The mammalian amygdala is a key emotional brain region for eliciting social behaviour,
critically involved in anxiety and fear-related behaviours, and hence a focus of research on …

Aging and increased amyloid burden are major risk factors for cognitive diseases such as
Alzheimer's disease (AD). Effective therapies for these diseases are lacking. Here, we …

Cell lineage specification is accomplished by a concerted action of chromatin remodeling
and tissue-specific transcription factors. However, the mechanisms that induce and maintain …

Social behaviour is regulated by activity of host-associated microbiota across multiple
species. However, the molecular mechanisms mediating this relationship remain elusive …

Schizophrenia is a devastating disease that arises on the background of genetic
predisposition and environmental risk factors, such as early life stress (ELS). In this study …

Nucleosomes composed of histone octamer and DNA are the basic structural unit in the
eukaryote chromosome. Under the stimulation of various factors, histones will undergo …