Bacterial drug resistance has become a global public health threat, among which the
infection of carbapenem-resistant Enterobacterales (CRE) is one of the top noticeable …

Although hypervirulent Klebsiella pneumoniae (hvKP) can produce community-acquired
infections that are fatal in young and adult hosts, such as pyogenic liver abscess …

Background Mobile colistin resistance (mcr) genes modify Lipid A molecules of the
lipopolysaccharide, changing the overall charge of the outer membrane. Results and …

The cell envelope is essential for survival and adaptation of bacteria. Bacterial membrane
proteins include the major porins that mediate the influx of nutrients and several classes of …

Infections caused by multi-drug resistant (MDR) bacterial pathogens are a leading cause of
mortality and morbidity across the world. Indiscriminate use of broad-spectrum antibiotics …

Klebsiella pneumoniae is an opportunistic pathogen belonging to the Enterobacteriaceae
family, which is the leading cause of nosocomial infections. The emergence of hypervirulent …

Klebsiella pneumoniae is one of the most common pathogens responsible for infections,
including pneumonia, urinary tract infections, and bacteremias. The increasing prevalence …

Gene regulatory networks allow organisms to generate coordinated responses to
environmental challenges. In bacteria, regulatory networks are re-wired and re-purposed …

With the rising incidences of antimicrobial resistance (AMR) and the diminishing options of
novel antimicrobial agents, it is paramount to decipher the molecular mechanisms of action …

Spread of the carbapenemase-encoding and mobilized colistin resistance (mcr) genes
among Enterobacteriales poses a great threat to global public health, especially when the …