The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …

Almost a quarter of a century ago, interleukin-6 (IL-6) was discovered as an inflammatory
cytokine involved in B cell differentiation. Today, IL-6 is recognized to be a highly versatile …

Background: Neuromyelitis optica (NMO) is assumed to be immunologically distinct from
multiple sclerosis (MS). Adequate studies about cytokines and chemokines in NMO have …

Intractable neuropathic pain is a frequent consequence of nerve injury or disease. When
peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann …

Summary ACOX1 (acyl-CoA oxidase 1) encodes the first and rate-limiting enzyme of the
very-long-chain fatty acid (VLCFA) β-oxidation pathway in peroxisomes and leads to H 2 O 2 …

After nerve injury, Schwann cells convert to a phenotype specialized to promote repair. But
during the slow process of axonal regrowth, these repair Schwann cells gradually lose their …

Purpose.: In glaucoma, the optic nerve head (ONH) is the principal site of initial axonal
injury, and elevated intraocular pressure (IOP) is the predominant risk factor. However, the …

Remyelination of the peripheral and central nervous systems (PNS and CNS, respectively)
is a prerequisite for functional recovery after lesion. However, this process is not always …

Objective The impact of glia cells during GI carcinogenesis and in cancer pain is unknown.
Here, we demonstrate a novel mechanism how Schwann cells (SCs) become activated in …

This paper addresses several basic issues that are important for the experimental model
design to investigate peripheral nerve regeneration. First, the importance of carrying out …