Leukodystrophies are genetically determined disorders characterized by the selective
involvement of the central nervous system white matter. Onset may be at any age, from …

Myelination by oligodendrocytes is a highly specialized process that relies on intimate
interactions between the axon and the oligodendrocytes. Astrocytes have an important part …

Astrocytes are the most abundant glial cell type in the central nervous system and are
essential to the development, plasticity, and maintenance of neural circuits. Astrocytes are …

Background Mutant mouse models suggest that the chloride channel ClC-2 has functions in
ion and water homoeostasis, but this has not been confirmed in human beings. We aimed to …

Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is characterised by
chronic white matter oedema. The disease has an infantile onset and leads to slow …

Astrocytes regulate central nervous system development, maintain its homeostasis and
orchestrate repair upon injury. Emerging evidence support functional specialization of …

Ion fluxes mediated by glial cells are required for several physiological processes such as
fluid homeostasis or the maintenance of low extracellular potassium during high neuronal …

Brain oedema is a life-threatening complication of various neurological conditions.
Understanding molecular mechanisms of brain volume regulation is critical for therapy …

Astrocytes have emerged as essential regulators of function and response to injury in the
brain and spinal cord, yet very little is known about regional differences that exist. Here we …

Defects in the astrocytic membrane protein MLC1, the adhesion molecule GlialCAM or the
chloride channel ClC-2 underlie human leukoencephalopathies. Whereas GlialCAM binds …