Simulating cancer behavior across multiple biological scales in space and time, ie,
multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine …

Overexpression of the human epidermal growth factor-2 (HER2) oncogene in human breast
carcinomas has been associated with a more aggressive course of disease. The reason for …

There have been many techniques developed in recent years to in silico model a variety of
cancer behaviors. Agent-based modeling is a specific discrete-based hybrid modeling …

Abstract Background The traditional Chinese Medicine (TCM) herbal formula Lian Hua Qing
Wen (LHQW) improves the results of COVID-19 treatment. Three very recent studies …

Despite the beneficial effects of estrogens in women's health, there is a plethora of evidence
that suggest an important role for these hormones, particularly 17β-estradiol (E2), in the …

Collective cell responses to exogenous cues depend on cell–cell interactions. In principle,
these can result in enhanced sensitivity to weak and noisy stimuli. However, this has not yet …

Although human epidermal growth factor receptor 2 (HER2) overexpression is implicated in
tumor progression for a variety of cancer types, how it dysregulates signaling networks …

Experimental evidence suggests that epidermal growth factor receptor (EGFR)-mediated
activation of the signaling protein phospholipase Cγ plays a critical role in a cancer cell's …

HER2 (human epidermal growth factor receptor-2; also known as erbB2) and its relatives
HER1 (epidermal growth factor receptor; EGFR), HER3 and HER4 belong to the HER family …

Phosphoinositide metabolism is crucial intracellular signaling system that regulates a
plethora of biological functions including mitogenesis, cell proliferation and division …