Regulated cell death (RCD) is pivotal in directing the severity and outcome of liver injury.
Hepatocyte cell death is a critical event in the progression of liver disease due to resultant …

Cell death represents a basic biological paradigm that governs outcomes and long-term
sequelae in almost every hepatic disease condition. Acute liver failure is characterized by …

Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in
western countries, and, because of translational relevance of animal models, APAP is …

Pyroptosis, apoptosis, necroptosis, and ferroptosis, which are the most well-studied
regulated cell death (RCD) pathways, contribute to the clearance of infected or potentially …

Tumour necrosis factor-α (TNF) is a multifunctional cytokine. First recognized as an
endogenous soluble factor that induces necrosis of solid tumours, TNF became increasingly …

Over the past 15 years, elegant studies have demonstrated that in certain conditions,
programed cell death resembles necrosis and depends on a unique molecular pathway with …

Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide.
However, due to its wide availability, it is frequently implicated in intentional or unintentional …

Necroptosis is a form of regulated cell death that critically depends on receptor-interacting
serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) and …

Nonalcoholic steatohepatitis (NASH) arises from a variable interplay between environmental
factors and genetic determinants that cannot be completely replicated in animals …

Background Drug-induced liver injury (DILI) is the most challenging and thought-provoking
liver problem for hepatologists owing to unregulated medication usage in medical practices …