Zygotic genome activation by the totipotency pioneer factor Nr5a2
Life begins with a switch in genetic control from the maternal to the embryonic genome
during zygotic genome activation (ZGA). Despite its importance, the essential regulators of …
during zygotic genome activation (ZGA). Despite its importance, the essential regulators of …
Structural basis for the inhibition of cGAS by nucleosomes
The cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS) senses
invasion of pathogenic DNA and stimulates inflammatory signaling, autophagy, and …
invasion of pathogenic DNA and stimulates inflammatory signaling, autophagy, and …
Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT
H Ehara, T Kujirai, M Shirouzu, H Kurumizaka… - Science, 2022 - science.org
During gene transcription, RNA polymerase II (RNAPII) traverses nucleosomes in chromatin,
but the mechanism has remained elusive. Using cryo–electron microscopy, we obtained …
but the mechanism has remained elusive. Using cryo–electron microscopy, we obtained …
Structural basis of the nucleosome transition during RNA polymerase II passage
T Kujirai, H Ehara, Y Fujino, M Shirouzu, S Sekine… - Science, 2018 - science.org
Genomic DNA forms chromatin, in which the nucleosome is the repeating unit. The
mechanism by which RNA polymerase II (RNAPII) transcribes the nucleosomal DNA …
mechanism by which RNA polymerase II (RNAPII) transcribes the nucleosomal DNA …
The fork protection complex promotes parental histone recycling and epigenetic memory
The inheritance of parental histones across the replication fork is thought to mediate
epigenetic memory. Here, we reveal that fission yeast Mrc1 (CLASPIN in humans) binds H3 …
epigenetic memory. Here, we reveal that fission yeast Mrc1 (CLASPIN in humans) binds H3 …
Structural insight into nucleosome transcription by RNA polymerase II with elongation factors
H Ehara, T Kujirai, Y Fujino, M Shirouzu, H Kurumizaka… - Science, 2019 - science.org
RNA polymerase II (RNAPII) transcribes chromosomal DNA that contains multiple
nucleosomes. The nucleosome forms transcriptional barriers, and nucleosomal transcription …
nucleosomes. The nucleosome forms transcriptional barriers, and nucleosomal transcription …
Interaction of the pioneer transcription factor GATA3 with nucleosomes
H Tanaka, Y Takizawa, M Takaku, D Kato… - Nature …, 2020 - nature.com
During cellular reprogramming, the pioneer transcription factor GATA3 binds chromatin, and
in a context-dependent manner directs local chromatin remodeling and enhancer formation …
in a context-dependent manner directs local chromatin remodeling and enhancer formation …
Cooperation between bHLH transcription factors and histones for DNA access
The basic helix–loop–helix (bHLH) family of transcription factors recognizes DNA motifs
known as E-boxes (CANNTG) and includes 108 members. Here we investigate how …
known as E-boxes (CANNTG) and includes 108 members. Here we investigate how …
Molecular and structural basis of the chromatin remodeling activity by Arabidopsis DDM1
A Osakabe, Y Takizawa, N Horikoshi… - Nature …, 2024 - nature.com
The histone H2A variant H2A. W occupies transposons and thus prevents access to them in
Arabidopsis thaliana. H2A. W is deposited by the chromatin remodeler DDM1, which also …
Arabidopsis thaliana. H2A. W is deposited by the chromatin remodeler DDM1, which also …
Designer Adaptor Proteins for Functional Conversion of Peptides to Small-Molecule Ligands toward In-Cell Catalytic Protein Modification
A Fujimura, H Ishida, T Nozaki, S Terada… - ACS Central …, 2023 - ACS Publications
Peptides are privileged ligands for diverse biomacromolecules, including proteins; however,
their utility is often limited due to low membrane permeability and in-cell instability. Here, we …
their utility is often limited due to low membrane permeability and in-cell instability. Here, we …