Sex-based differences in cardiometabolic biomarkers

J Lew, M Sanghavi, CR Ayers, DK McGuire, T Omland… - Circulation, 2017 - Am Heart Assoc
Background: Few data are available comparing cardiovascular disease (CVD) biomarker
profiles between women and men in the general population. We analyzed sex-based …

Novel biosynthesis, metabolism and physiological functions of L-homoarginine

S Adams, D Che, G Qin, MH Farouk… - Current Protein and …, 2019 - ingentaconnect.com
L-Homoarginine (hArg)((2S)-amino-6-Carbamimidamidohexanoic acid) is a non-essential
cationic amino acid that may be synthesised from the lysine catabolism or the …

Homoarginine in the cardiovascular system: Pathophysiology and recent developments

V Koch, LD Gruenewald, T Gruber‐Rouh… - Fundamental & …, 2023 - Wiley Online Library
Upcoming experimental and epidemiological data have identified the endogenous non‐
proteinogenic amino acid L‐homoarginine (L‐hArg) not only as a novel biomarker for …

Oral supplementation with L‐homoarginine in young volunteers

D Atzler, M Schönhoff, K Cordts… - British journal of …, 2016 - Wiley Online Library
Aims Low blood concentrations of the naturally occurring amino acid L‐homoarginine (L‐
hArg) are related to impaired cardiovascular outcome and mortality in humans and animals …

The prognostic biomarker L-homoarginine is a substrate of the cationic amino acid transporters CAT1, CAT2A and CAT2B

A Chafai, MF Fromm, J König, R Maas - Scientific reports, 2017 - nature.com
Low plasma concentration of L-homoarginine is an independent predictor of cardiovascular
events and total mortality. Experimental data indicate that supplementation of L …

The role of l-arginine/l-homoarginine/nitric oxide pathway for aortic distensibility and intima-media thickness in stroke patients

A Haghikia, GR Yanchev, AA Kayacelebi, E Hanff… - Amino Acids, 2017 - Springer
Asymmetric dimethylarginine (ADMA) and l-homoarginine (hArg) are l-arginine (Arg)
metabolites derived from different pathways. Protein arginine N-methyltransferase (PRMT) …

Homoarginine Associates with Carotid Intima-Media Thickness and Atrial Fibrillation and Predicts Adverse Events after Stroke

L Schwieren, M Jensen, R Schulz, S Lezius, E Laxy… - Life, 2023 - mdpi.com
Homoarginine is associated with cardio-and cerebrovascular morbidity and mortality.
However, the underlying pathomechanisms remain elusive. Here, we evaluated the …

Population kinetics of homoarginine and optimized supplementation for cardiovascular risk reduction

CJ Kleist, CU Choe, D Atzler, M Schönhoff, R Böger… - Amino Acids, 2022 - Springer
Homoarginine is an endogenous amino acid whose levels are reduced in patients with
renal, cardio-and cerebrovascular disease. Moreover, low homoarginine concentrations …

Association of lower plasma homoarginine concentrations with greater risk of all-cause mortality in the community: the Framingham Offspring Study

E Schwedhelm, RJ Song, RS Vasan… - Journal of Clinical …, 2020 - mdpi.com
Lower circulating homoarginine concentrations have been associated with morbidity and
mortality in patients with established cardiovascular disease (CVD). We assayed plasma …

L‐homoarginine is associated with decreased cardiovascular‐and all‐cause mortality

MC Mokhaneli, S Botha‐Le Roux… - European journal of …, 2021 - Wiley Online Library
Background Increasing evidence suggests that L‐homoarginine, an endogenous analogue
of the amino acid L‐arginine, may have beneficial effects on vascular homeostasis. We …