Shaping bacterial gene expression by physiological and proteome allocation constraints

M Scott, T Hwa - Nature Reviews Microbiology, 2023 - nature.com
Networks of molecular regulators are often the primary objects of focus in the study of gene
regulation, with the machinery of protein synthesis tacitly relegated to the background …

Unique roles in health promotion of dietary flavonoids through gut microbiota regulation: Current understanding and future perspectives

Z Li, Z Ren, L Zhao, L Chen, Y Yu, D Wang, X Mao… - Food Chemistry, 2023 - Elsevier
Advances in understanding the biological effects of dietary flavonoids and flavonoid-rich
foods have been reported. Improving knowledge about their beneficial effects, and …

Flavonoids and gastrointestinal health: single molecule for multiple roles

H Lan, H Wang, C Chen, W Hu, C Ai… - Critical Reviews in …, 2024 - Taylor & Francis
Diet can be considered as one of the pivotal factors in regulating gastrointestinal health, and
polyphenols widely distributed in human daily diet. The polyphenols and their metabolites …

Stringent response ensures the timely adaptation of bacterial growth to nutrient downshift

M Zhu, X Dai - Nature Communications, 2023 - nature.com
Timely adaptation to nutrient downshift is crucial for bacteria to maintain fitness during feast
and famine cycle in the natural niche. However, the molecular mechanism that ensures the …

Defined microbial mixed culture for utilization of polyurethane monomers

RNC Utomo, WJ Li, T Tiso, C Eberlein… - ACS sustainable …, 2020 - ACS Publications
The end-of-life plastic crisis is very prominent in the research area and even in the public
realm. Especially, for plastic polymers that are difficult to recycle via traditional routes such …

Predictive biology: modelling, understanding and harnessing microbial complexity

AJ Lopatkin, JJ Collins - Nature Reviews Microbiology, 2020 - nature.com
Predictive biology is the next great chapter in synthetic and systems biology, particularly for
microorganisms. Tasks that once seemed infeasible are increasingly being realized such as …

Suboptimal resource allocation in changing environments constrains response and growth in bacteria

R Balakrishnan, RT de Silva, T Hwa… - Molecular systems …, 2021 - embopress.org
To respond to fluctuating conditions, microbes typically need to synthesize novel proteins.
As this synthesis relies on sufficient biosynthetic precursors, microbes must devise effective …

Enzyme expression kinetics by Escherichia coli during transition from rich to minimal media depends on proteome reserves

C Wu, M Mori, M Abele, A Banaei-Esfahani… - Nature …, 2023 - nature.com
Bacterial fitness depends on adaptability to changing environments. In rich growth medium,
which is replete with amino acids, Escherichia coli primarily expresses protein synthesis …

A new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity

JH Jeong, JS Han, Y Jung, SM Lee, SH Park… - Nature …, 2023 - nature.com
Dietary restriction (DR) delays aging and the onset of age-associated diseases. However, it
is yet to be determined whether and how restriction of specific nutrients promote longevity …

Nutrient dominance governs the assembly of microbial communities in mixed nutrient environments

S Estrela, A Sanchez-Gorostiaga, JCC Vila, A Sanchez - Elife, 2021 - elifesciences.org
A major open question in microbial community ecology is whether we can predict how the
components of a diet collectively determine the taxonomic composition of microbial …