Immune-mediated approaches against COVID-19

HF Florindo, R Kleiner, D Vaskovich-Koubi… - Nature …, 2020 - nature.com
Abstract The coronavirus disease-19 (COVID-19) is caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). The long incubation period of this new virus, which …

The pathogenesis of sepsis and potential therapeutic targets

M Huang, S Cai, J Su - International journal of molecular sciences, 2019 - mdpi.com
Sepsis is defined as “a life-threatening organ dysfunction caused by a host's dysfunctional
response to infection”. Although the treatment of sepsis has developed rapidly in the past …

The diverse function of PD-1/PD-L pathway beyond cancer

W Qin, L Hu, X Zhang, S Jiang, J Li, Z Zhang… - Frontiers in …, 2019 - frontiersin.org
The recent success of PD-1 and PD-L1 blockade in cancer therapy illustrates the important
role of the PD-1/PD-L1 pathway in the regulation of antitumor immune responses. However …

Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis

C Cao, M Yu, Y Chai - Cell death & disease, 2019 - nature.com
Sepsis is a life-threatening organ dysfunction syndrome caused by dysregulated host
response to infection that leads to uncontrolled inflammatory response followed by …

Chronic implant-related bone infections—can immune modulation be a therapeutic strategy?

E Seebach, KF Kubatzky - Frontiers in immunology, 2019 - frontiersin.org
Chronic implant-related bone infections are a major problem in orthopedic and trauma-
related surgery with severe consequences for the affected patients. As antibiotic resistance …

Parallels in sepsis and COVID-19 conditions: implications for managing severe COVID-19

CO Olwal, NN Nganyewo, K Tapela… - Frontiers in …, 2021 - frontiersin.org
Sepsis is a life-threatening systemic illness attributed to a dysregulated host response to
infection. Sepsis is a global burden killing~ 11 million persons annually. In December 2019 …

CD4 T cell responses and the sepsis-induced immunoparalysis state

MD Martin, VP Badovinac, TS Griffith - Frontiers in immunology, 2020 - frontiersin.org
Sepsis remains a major cause of death in the United States and worldwide, and costs
associated with treating septic patients place a large burden on the healthcare industry …

PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow

Y Yu, RR Wang, NJ Miao, JJ Tang, YW Zhang… - Nature …, 2022 - nature.com
Programmed death ligand 1 (PD-L1) has been shown to be inducibly expressed on
neutrophils to suppress host immunity during polymicrobial sepsis, virus and parasite …

[HTML][HTML] Integrating molecular pathogenesis and clinical translation in sepsis-induced acute respiratory distress syndrome

JA Englert, C Bobba, RM Baron - JCI insight, 2019 - ncbi.nlm.nih.gov
Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and
mortality and arises after lung infection or infection at extrapulmonary sites. An aberrant host …

PD-L1 dysregulation in COVID-19 patients

F Sabbatino, V Conti, G Franci, C Sellitto… - Frontiers in …, 2021 - frontiersin.org
The COVID-19 pandemic has reached direct and indirect medical and social consequences
with a subset of patients who rapidly worsen and die from severe-critical manifestations. As …