The immune system is coordinated by an intricate network of stimulatory and inhibitory
circuits that regulate host responses against endogenous and exogenous insults. Disruption …

The immune response to Candida species is shaped by the commensal character of the
fungus. There is a crucial role for discerning between colonization and invasion at mucosal …

Candida albicans is a common fungal pathogen of humans that colonizes the skin and
mucosal surfaces of most healthy individuals. Until recently, little was known about the …

The interaction between Candida albicans and its host cells is characterized by a complex
interplay between the expression of fungal virulence factors, which results in adherence …

Fungal diseases represent an important paradigm in immunology, as they can result from
either a lack of recognition by the immune system or overactivation of the inflammatory …

Myeloid cells are key drivers of physiological responses to pathogen invasion or tissue
damage. Members of the C-type lectin receptor (CLR) family stand out among the …

Candida albicans is a human opportunist pathogen that can grow as yeast, pseudohyphae,
or true hyphae in vitro and in vivo, depending on environmental conditions. Reversible …

Our understanding of immunity to fungal pathogens has advanced considerably in recent
years. Particularly significant have been the parallel discoveries in the C-type lectin receptor …

C-type lectin receptors (CLRs) comprise a heterogeneous group of transmembrane proteins.
Many of them are expressed in myeloid cells and signal in response to pathogen-derived or …

Innate immune cells detect pathogens via pattern recognition receptors (PRRs), which
signal for initiation of immune responses to infection. Studies with Dectin-1, a PRR for fungi …