The renal nerves are the communication link between the central nervous system and the
kidney. In response to multiple peripheral and central inputs, efferent renal sympathetic …

Calcineurin is a eukaryotic Ca2+-and calmodulin-dependent serine/threonine protein
phosphatase. It is a heterodimeric protein consisting of a catalytic subunit calcineurin A …

Excessive sodium (Na+) in salinized soils inhibits plant growth and development. A mutation
in the SOS3 gene renders Arabidopsis thaliana plants hypersensitive to Na+-induced …

The role of protein phosphatases in the regulation of cellular processes is now well
established (1, 2). Calcineurin (also called protein phosphatase 2B), a major calmodulin …

The Na+-K+-ATPase, or sodium pump, is the membrane-bound enzyme that maintains the
Na+ and K+ gradients across the plasma membrane of animal cells. Because of its …

The kidney is innervated with efferent sympathetic nerve fibers that directly contact the
vasculature, the renal tubules, and the juxtaglomerular granular cells. Via specific …

Calcineurin is a conserved Ca2+/calmodulin-dependent protein phosphatase that plays a
critical role in Ca2+ signaling. We describe new components of a calcineurin-mediated …

Tubular reabsorption of filtered sodium is quantitatively the main contribution of kidneys to
salt and water homeostasis. The transcellular reabsorption of sodium proceeds by a two …

The PMC1 gene in Saccharomyces cerevisiae encodes a vacuolar Ca2+ ATPase required
for growth in high-Ca2+ conditions. Previous work showed that Ca2+ tolerance can be …

INTRODUCTION Phosphorylation of structural and regulatory proteins is a major
intracellular control mechanism in eukaryotes. The phosphoryl-ation state of a protein is a …