Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications

J Ren, NN Wu, S Wang, JR Sowers… - Physiological …, 2021 - journals.physiology.org
The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …

The progression of hypertensive heart disease

MH Drazner - Circulation, 2011 - Am Heart Assoc
Hypertensive heart disease is a constellation of abnormalities that includes left ventricular
hypertrophy (LVH), systolic and diastolic dysfunction, and their clinical manifestations …

Evidence supporting the existence of a distinct obese phenotype of heart failure with preserved ejection fraction

M Obokata, YNV Reddy, SV Pislaru, V Melenovsky… - Circulation, 2017 - Am Heart Assoc
Background: Heart failure (HF) with preserved ejection fraction (HFpEF) is a heterogeneous
syndrome. Phenotyping patients into pathophysiologically homogeneous groups may …

Sodium glucose transporter 2 (SGLT2) inhibition with empagliflozin improves cardiac diastolic function in a female rodent model of diabetes

J Habibi, AR Aroor, JR Sowers, G Jia… - Cardiovascular …, 2017 - Springer
Obese and diabetic individuals are at increased risk for impairments in diastolic relaxation
and heart failure with preserved ejection fraction. The impairments in diastolic relaxation are …

Cardiac remodeling in obesity

ED Abel, SE Litwin, G Sweeney - Physiological reviews, 2008 - journals.physiology.org
The dramatic increase in the prevalence of obesity and its strong association with
cardiovascular disease have resulted in unprecedented interest in understanding the effects …

Prognostic implications of left ventricular hypertrophy

BA Vakili, PM Okin, RB Devereux - American heart journal, 2001 - Elsevier
Background To date there has been no comprehensive review of the association between
left ventricular hypertrophy (LVH) at baseline and subsequent adverse clinical events …

Effect of growth on variability of left ventricular mass: assessment of allometric signals in adults and children and their capacity to predict cardiovascular risk

G De Simone, RB Devereux, SR Daniels… - Journal of the American …, 1995 - Elsevier
OBJECTIVES.: We sought to determine whether growth influences the relation between left
ventricular mass and body size and whether use of different body size indexes affects the …

Alterations of left ventricular myocardial characteristics associated with obesity

CY Wong, T O'Moore-Sullivan, R Leano, N Byrne… - Circulation, 2004 - Am Heart Assoc
Background—Obesity is associated with heart failure, but an effect of weight, independent of
comorbidities, on cardiac structure and function is not well established. We sought whether …

Effect of obesity and overweight on left ventricular diastolic function: a community-based study in an elderly cohort

C Russo, Z Jin, S Homma, T Rundek… - Journal of the American …, 2011 - jacc.org
Objectives: The purpose of this study was to assess the independent effect of increased
body size on left ventricular (LV) diastolic function. Background: Obese and overweight …

Sex and race differences in right ventricular structure and function: the Multi-Ethnic Study of Atherosclerosis–Right Ventricle Study

SM Kawut, JAC Lima, RG Barr, H Chahal, A Jain… - Circulation, 2011 - Am Heart Assoc
Background—Right ventricular (RV) morphology is an important predictor of outcomes in
heart and lung disease; however, determinants of RV anatomy have not been well studied …