Synaptopathology involved in autism spectrum disorder

S Guang, N Pang, X Deng, L Yang, F He… - Frontiers in cellular …, 2018 - frontiersin.org
Autism spectrum disorder (ASD) encompasses a group of multifactorial neurodevelopmental
disorders characterized by impaired social communication, social interaction and repetitive …

Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders

R Gao, P Penzes - Current molecular medicine, 2015 - ingentaconnect.com
Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …

Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors

PE Rothwell, MV Fuccillo, S Maxeiner, SJ Hayton… - Cell, 2014 - cell.com
In humans, neuroligin-3 mutations are associated with autism, whereas in mice, the
corresponding mutations produce robust synaptic and behavioral changes. However …

Fundamental elements in autism: from neurogenesis and neurite growth to synaptic plasticity

J Gilbert, HY Man - Frontiers in cellular neuroscience, 2017 - frontiersin.org
Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with a high
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …

Dendritic spines: the locus of structural and functional plasticity

C Sala, M Segal - Physiological reviews, 2014 - journals.physiology.org
The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …

Neuroligins and neurexins link synaptic function to cognitive disease

TC Südhof - Nature, 2008 - nature.com
The brain processes information by transmitting signals at synapses, which connect neurons
into vast networks of communicating cells. In these networks, synapses not only transmit …

Advances in autism genetics: on the threshold of a new neurobiology

BS Abrahams, DH Geschwind - Nature reviews genetics, 2008 - nature.com
Autism is a heterogeneous syndrome defined by impairments in three core domains: social
interaction, language and range of interests. Recent work has led to the identification of …

A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice

K Tabuchi, J Blundell, MR Etherton, RE Hammer, X Liu… - science, 2007 - science.org
Autism spectrum disorders (ASDs) are characterized by impairments in social behaviors that
are sometimes coupled to specialized cognitive abilities. A small percentage of ASD patients …

Autism genetics

AM Persico, V Napolioni - Behavioural brain research, 2013 - Elsevier
Autism spectrum disorder (ASD) is a severe neuropsychiatric disease with strong genetic
underpinnings. However, genetic contributions to autism are extremely heterogeneous, with …

Neuroligins determine synapse maturation and function

F Varoqueaux, G Aramuni, RL Rawson, R Mohrmann… - Neuron, 2006 - cell.com
Synaptogenesis, the generation and maturation of functional synapses between nerve cells,
is an essential step in the development of neuronal networks in the brain. It is thought to be …