[HTML][HTML] miRNA-based biomarkers, therapies, and resistance in Cancer

B He, Z Zhao, Q Cai, Y Zhang, P Zhang… - … journal of biological …, 2020 - ncbi.nlm.nih.gov
Abstract MicroRNAs (miRNAs), small non-coding RNAs (ncRNAs) of about 22 nucleotides in
size, play important roles in gene regulation, and their dysregulation is implicated in human …

Overview of microRNA biogenesis, mechanisms of actions, and circulation

J O'Brien, H Hayder, Y Zayed, C Peng - Frontiers in endocrinology, 2018 - frontiersin.org
MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in regulating
gene expression. The majority of miRNAs are transcribed from DNA sequences into primary …

Mechanisms of action and clinical implications of MicroRNAs in the drug resistance of gastric cancer

Y Liu, X Ao, G Ji, Y Zhang, W Yu, J Wang - Frontiers in oncology, 2021 - frontiersin.org
Gastric cancer (GC) is one of the most common malignant tumors of digestive systems
worldwide, with high recurrence and mortality. Chemotherapy is still the standard treatment …

Non-canonical targets destabilize microRNAs in human Argonautes

JH Park, SY Shin, C Shin - Nucleic acids research, 2017 - academic.oup.com
Although much is known about microRNA (miRNA) biogenesis and the mechanism by which
miRNAs regulate their targets, little is known about the regulation of miRNA stability. Mature …

Skeletal muscle-derived exosomal miR-146a-5p inhibits adipogenesis by mediating muscle-fat axis and targeting GDF5-PPARγ signaling

M Qin, L Xing, J Wu, S Wen, J Luo, T Chen… - International Journal of …, 2023 - mdpi.com
Skeletal muscle-fat interaction is essential for maintaining organismal energy homeostasis
and managing obesity by secreting cytokines and exosomes, but the role of the latter as a …

Retrograde trafficking of Argonaute 2 acts as a rate-limiting step for de novo miRNP formation on endoplasmic reticulum–attached polysomes in mammalian cells

M Bose, S Chatterjee, Y Chakrabarty… - Life science …, 2020 - life-science-alliance.org
microRNAs are short regulatory RNAs in metazoan cells. Regulation of miRNA activity and
abundance is evident in human cells where availability of target messages can influence …

MotomiRs: miRNAs in motor neuron function and disease

ZCE Hawley, D Campos-Melo… - Frontiers in Molecular …, 2017 - frontiersin.org
MiRNAs are key regulators of the mammalian transcriptome that have been increasingly
linked to degenerative diseases of the motor neurons. Although many of the miRNAs …

Non-canonical argonaute loading of extracellular vesicle-derived exogenous single-stranded miRNA in recipient cells

B Ghoshal, E Bertrand… - Journal of cell …, 2021 - journals.biologists.com
MicroRNAs (miRNAs), the tiny regulators of gene expression, can be transferred between
neighbouring cells via extracellular vesicles (EVs) to control the expression of genes in both …

Intracytoplasmic re-localization of miRISC complexes

B Akgül, İ Erdoğan - Frontiers in Genetics, 2018 - frontiersin.org
MicroRNAs (miRNAs) are a conserved class of non-coding RNAs of 22 nucleotides that post-
transcriptionally regulate gene expression through translational repression and/or mRNA …

MicroRNA (miRNA)-to-miRNA regulation of programmed cell death 4 (PDCD4)

P Ajuyah, M Hill, A Ahadi, J Lu… - Molecular and cellular …, 2019 - Am Soc Microbiol
The regulation of tumor suppressor genes by microRNAs (miRNAs) is often demonstrated as
a one-miRNA-to-one-target relationship. However, given the large number of miRNA sites …