B-cell lymphoma 2 (BCL-2) family proteins primarily work as a programmed cell death
regulator, whereby multiple interactions between them determine cell survival. This explains …

Apoptosis is a critical process for the maintenance of tissue homeostasis and prevention of
tumorigenesis. The members of the Bcl-2 family of proteins are the central regulators of the …

The discovery of B-cell lymphoma-2 (BCL-2) over 20 years ago revealed a new paradigm in
cancer biology: the development and persistence of cancer can be driven by molecular …

Abstract Purpose: Overexpression of Bcl-2 protein has been observed in more than 80% of
B-cell lymphomas, including diffuse large cell lymphoma (DLCL), the most common subtype …

Tumor cell survival is highly dependent on the expression of certain pro-survival Bcl-2 family
proteins. An attractive therapeutic approach is to inhibit these proteins using agents that …

Study Design. Establishment of a novel in vivo animal model of cervical spondylosis.
Objective. To investigate apoptotic, degenerative, and inflammatory changes occurring in …

Genotoxic stress triggers a rapid translocation of p53 to the mitochondria, contributing to
apoptosis in a transcription-independent manner. Using immunopurification protocols and …

Alanine scanning has been widely employed as a method of identifying side chains that play
important roles in protein–protein and protein–peptide interactions. Here we show how an …

Until recently, most research efforts aimed at developing anti-cancer tools were focusing on
small molecules. Alternative compounds are now being increasingly assessed for their …

Head, neck squamous cell carcinomas (HNSCCs) are frequently characterized by
chemotherapy, radiation resistance, by overexpression of Bcl-X L, an antiapoptotic member …