The emerging roles of circRNAs in cancer and oncology

LS Kristensen, T Jakobsen, H Hager… - Nature reviews Clinical …, 2022 - nature.com
Over the past decade, circular RNAs (circRNAs) have emerged as a large class of primarily
non-coding RNA molecules, many of which have key roles in cancer development and …

[HTML][HTML] Circular RNA: metabolism, functions and interactions with proteins

WY Zhou, ZR Cai, J Liu, DS Wang, HQ Ju, RH Xu - Molecular cancer, 2020 - Springer
Abstract Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules
that are ubiquitous across species ranging from viruses to mammals. Important advances …

[HTML][HTML] Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis

JF Lin, PS Hu, YY Wang, YT Tan, K Yu, K Liao… - Signal transduction and …, 2022 - nature.com
Metabolic enzymes have an indispensable role in metabolic reprogramming, and their
aberrant expression or activity has been associated with chemosensitivity. Hence, targeting …

[HTML][HTML] Going circular: history, present, and future of circRNAs in cancer

G Pisignano, DC Michael, TH Visal, R Pirlog… - Oncogene, 2023 - nature.com
To date, thousands of highly abundant and conserved single-stranded RNA molecules
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …

[HTML][HTML] The circular RNA circDLG1 promotes gastric cancer progression and anti-PD-1 resistance through the regulation of CXCL12 by sponging miR-141-3p

DL Chen, H Sheng, DS Zhang, Y Jin, BT Zhao… - Molecular Cancer, 2021 - Springer
Abstract Background Dysregulation of circular RNAs (circRNAs) plays an important role in
the development of gastric cancer; thus, revealing the biological and molecular mechanisms …

circRNA_010383 acts as a sponge for miR-135a, and its downregulated expression contributes to renal fibrosis in diabetic nephropathy

F Peng, W Gong, S Li, B Yin, C Zhao, W Liu, X Chen… - Diabetes, 2021 - Am Diabetes Assoc
Diabetic nephropathy (DN), a vascular complication of diabetes, is the leading cause of
death in patients with diabetes. The contribution of aberrantly expressed circular RNAs …

[HTML][HTML] Circular RNAs in cancer: limitations in functional studies and diagnostic potential

F Li, Q Yang, AT He, BB Yang - Seminars in cancer biology, 2021 - Elsevier
Circular RNAs (circRNAs) are a large class of noncoding RNAs, generated from a process
called back-splicing, that possess critical regulatory functions in many cellular events. A …

[HTML][HTML] Novel genetic and epigenetic biomarkers of prognostic and predictive significance in stage II/III colorectal cancer

XJ Luo, Q Zhao, J Liu, JB Zheng, MZ Qiu, HQ Ju… - Molecular Therapy, 2021 - cell.com
The therapeutic strategies of stage II/III colorectal cancer (CRC) patients after curative
surgery remain controversial. In the clinical decision-making process, oncologists need to …

[HTML][HTML] A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer

R Song, P Guo, X Ren, L Zhou, P Li, NA Rahman… - Molecular cancer, 2023 - Springer
Abstract Background The treatment of Triple-negative breast cancer (TNBC) has always
been challenging due to its heterogeneity and the absence of well-defined molecular …

[HTML][HTML] FOXQ1-mediated SIRT1 upregulation enhances stemness and radio-resistance of colorectal cancer cells and restores intestinal microbiota function by …

M Yang, Q Liu, M Dai, R Peng, X Li, W Zuo… - Journal of Experimental …, 2022 - Springer
Background Resistance of colorectal cancer (CRC) cells to radiotherapy considerably
contributes to poor clinical outcomes of CRC patients. Microarray profiling in this study …