Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract, accounting for
the second most common cause of gastrointestinal tumors. As one of the intestinal barriers …

Wnt/β‐catenin/transcription factor (TCF) transcriptional activity plays an integral role in
colorectal cancer (CRC) carcinogenesis. However, to date, no drugs targeting this pathway …

The etiology of gastrointestinal (GI) diseases is intricate and multifactorial, encompassing
complex interactions between genetic predisposition and gut microbiota. The cell fate …

Background Colorectal cancer (CRC) development is a complex, multi-stage process,
transitioning from normal to adenomatous tissue, and then to invasive carcinoma. Despite …

Although organoids derived from tumor tissues have been widely used in cancer research, it
is a great challenge for cultured organoids to retain the characteristics of the original tumor …

Dysregulated fatty acid metabolism is an attractive therapeutic target for colorectal cancer
(CRC). We previously reported that fatty acid synthase (FASN), a key enzyme of de novo …

As a vital negative regulator of Wnt signaling pathway, human Notum (hNotum) plays a
crucial regulatory role in the progression of many human diseases. Deciphering the …

The contribution of deubiquitylating enzymes (DUBs) to β-Catenin stabilization in intestinal
stem cells and colorectal cancer (CRC) is poorly understood. Here, and by using an …

Colorectal cancer (CRC) is one of the most common malignancies worldwide and a leading
cause of cancer-related deaths. The vast majority of CRCs harbour a mutation in tumour …

Introduction APC and TP53 are the two most regularly mutated genes in colon
adenocarcinoma (COAD), especially in progressive malignancies and antitumoral immune …