The most commonly prescribed oral anticoagulants worldwide are the vitamin K antagonists
(VKAs) such as warfarin. Factors affecting the pharmacokinetics of VKAs are important …

The vitamin K antagonist is a commonly prescribed effective oral anticoagulant with a
narrow therapeutic range, and the dose requirements for different patients varied greatly. In …

Background Warfarin is known for its interaction with many drugs, resulting in undesired
treatment outcomes such as bleeding. The study aimed to assess the prevalence of drug …

The purpose of this paper is to study the genetic polymorphisms of related gene loci
(CYP2C9* 3, VKORC1-1639G> A) based on demographic and clinical factors, and use the …

The recent development and marketing of novel direct oral anticoagulants (DOACs)
represents a paradigm shift in the management of patients requiring long-term …

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A varfarina é um anticoagulante oral com eficácia clínica consagrada e custo relativamente
baixo. No entanto, sua estreita faixa terapêutica e as potenciais interações exigem …

The objective of this study was to investigate the influence of simultaneous factors that
potentially keep patients far from achieving target INR range at discharge in hospitalized …

Background Guidelines advise the use of antibacterials (ABs) in the management of COPD
exacerbations. COPD patients often have multiple comorbidities, such as diabetes mellitus …

Data science is making increasing contributions to pharmacovigilance. Although the
technical innovation of these works are indisputable, efficient progress in real-world …