Ferroptosis is one of the recently described types of cell death which is dependent on many
factors, including the accumulation of iron and lipid peroxidation. Its induction requires …

Ferritin is a ubiquitous protein that is present in most tissues as a cytosolic protein. The
major and common role of ferritin is to bind Fe2+, oxidize it and sequester it in a safe form in …

Aging affects iron homeostasis, as evidenced by tissue iron loading and anemia in the
elderly. Iron needs in mammals are met primarily by iron recycling from senescent red blood …

The recently presented Azalea Hypothesis for Alzheimer's disease asserts that iron
becomes sequestered, leading to a functional iron deficiency that contributes to …

Gaucher disease (GD) is caused by glucocerebrosidase deficiency leading to the
accumulation of sphingolipids in macrophages named “Gaucher's Cells”. These cells are …

Hematologists are frequently involved in the diagnostic pathway of Gaucher disease type 1
(GD1) patients since they present several hematological signs. However, GD1 is mainly …

Background: Hepcidin encoded by HAMP is vital to regulating proliferation, metastasis, and
migration. Hepcidin is secreted specifically by the liver. This study sought to examine the …

Gaucher disease (GD), a rare lysosomal storage disorder caused by deficient
glucocerebrosidase activity and consequent accumulation of glycosphingolipids in the …

Hepcidin is the hyposideremic hormone regulating iron metabolism. It is a defensin-like
disulfide-bonded peptide with antimicrobial activity. The main site of hepcidin production is …

Background & aims Gaucher disease (GD) is a multisystemic disease. Liver involvement in
GD is not well characterised and ranges from hepatomegaly to cirrhosis and hepatocellular …