The clinical responses observed following treatment with immune checkpoint inhibitors
(ICIs) support immunotherapy as a potential anticancer treatment. However, a large …

Comprising the majority of leukocytes in humans, neutrophils are the first immune cells to
respond to inflammatory or infectious etiologies and are crucial participants in the proper …

The bromodomain and extraterminal (BET) protein BRD4 is a validated drug target in
leukemia, yet its regulatory function in this disease is not well understood. Here, we show …

Starting with multipotent progenitors, hematopoietic lineages are specified by lineage-
restricted transcription factors. The transcription factors that determine the decision between …

In recent years, great progress has been made in elucidating the progenitor-cell hierarchy of
the myeloid lineage. Transcription factors have been shown to be key determinants in the …

The transcription factor C/EBPα is required for granulopoiesis and frequently disrupted in
human acute myeloid leukemia (AML). Here, we show disruption of C/EBPα blocks the …

PU. 1 directs the hematopoietic stem cell to the lymphoid-myeloid progenitor (LMP) and
interacts with GATA-binding protein 1 to inhibit commitment to the megakaryocyte-erythroid …

During'emergency'situations such as infections, host defense requires rapid mobilization of
bone marrow granulocyte progenitors.'Steady-state'granulopoiesis is absolutely dependent …

Prospective isolation of hematopoietic stem and progenitor cells has identified the lineal
relationships among all blood-cell types and has allowed their developmental mechanisms …

In recent years, a link between the transcriptional regulators of lineage-specific gene
expression and progenitor proliferation control has emerged. A main exponent of this …