Mitochondria are multifaceted organelles with key roles in anabolic and catabolic
metabolism, bioenergetics, cellular signalling and nutrient sensing, and programmed cell …

Ongoing efforts to generate a complete and accurate annotation of the genome have
revealed a significant blind spot for small proteins (< 100 amino acids) originating from short …

Advances in proteogenomic technologies have revealed hundreds to thousands of
translated small open reading frames (sORFs) that encode microproteins in genomes across …

In recent years, proteogenomics and ribosome profiling studies have identified a large
number of proteins encoded by noncoding regions in the human genome. They are …

Genomic studies of bacteria have long pointed toward widespread prevalence of small open
reading frames (sORFs) encoding for short proteins,< 100 amino acids in length. Despite the …

Since the advent of sequencing techniques and due to their continuous evolution, it has
become easier and less expensive to obtain the complete genome sequence of any …

In this study, we investigated two variants of a three-helix bundle and SH3-type barrel,
compact in space, present in small and large proteins of various living organisms. Using a …

The ever-growing repertoire of genomic techniques continues to expand our understanding
of the true diversity and richness of prokaryotic genomes. Riboproteogenomics laid the …

Accumulating evidence has shown that a large number of short open reading frames
(sORFs) also have the ability to encode proteins. The discovery of sORFs opens up a new …

In recent years, it has become evident that the true complexity of bacterial proteomes
remains underestimated. Gene annotation tools are known to propagate biases and …