Abstract Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular
signalling in response to extracellular stimuli. Hyperactivation of PI3K signalling cascades is …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Phosphoinositide 3-kinases (PI3Ks) are implicated in a broad spectrum of cellular activities,
such as growth, proliferation, differentiation, migration, and metabolism. Activation of class I …

The class I phosphoinositide 3-kinases (PI3Ks) are lipid kinases that transduce a host of
cellular signals and regulate a broad range of essential functions including growth …

The Class I phosphoinositide 3-kinases (PI3Ks) are a group of heterodimeric lipid kinases
that regulate crucial cellular processes including proliferation, survival, growth, and …

Genetic approaches have shown that the p110β isoform of class Ia phosphatidylinositol-3-
kinase (PI3K) is essential for the growth of PTEN-null tumors. Thus, it is desirable to develop …

Summary Phosphoinositide 3-kinases (PI3Ks) are essential for cell growth, migration, and
survival. The structure of a p110β/p85β complex identifies an inhibitory function for the C …

Synergistic activation by heterotrimeric guanine nucleotide–binding protein (G protein)–
coupled receptors (GPCRs) and receptor tyrosine kinases distinguishes p110β from other …

Class Ia phosphatidylinositol 3 kinase (PI3K) is required for oncogenic receptor-mediated
transformation; however, the individual roles of the two commonly expressed class Ia PI3K …

Phosphatidylinositol 3-kinases (PI3Ks) are important therapeutic targets for the treatment of
cancer, thrombosis, and inflammatory and immune diseases. The four highly homologous …