Roles, functions, and mechanisms of long non-coding RNAs in cancer

Y Fang, MJ Fullwood - Genomics, Proteomics and …, 2016 - academic.oup.com
Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in
chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through …

The rise of regulatory RNA

KV Morris, JS Mattick - Nature Reviews Genetics, 2014 - nature.com
Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …

[HTML][HTML] Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in squamous cell carcinoma of tongue

RS Zhou, EX Zhang, QF Sun, ZJ Ye, JW Liu, DH Zhou… - BMC cancer, 2019 - Springer
Background Numerous studies have highlighted that long non-coding RNAs (lncRNAs) can
bind to microRNA (miRNA) sites as competing endogenous RNAs (ceRNAs), thereby …

[HTML][HTML] Long noncoding RNAs in cancer: mechanisms of action and technological advancements

N Bartonicek, JLV Maag, ME Dinger - Molecular cancer, 2016 - Springer
The previous decade has seen long non-coding RNAs (lncRNAs) rise from obscurity to
being defined as a category of genetic elements, leaving its mark on the field of cancer …

Long noncoding RNA and cancer: a new paradigm

A Bhan, M Soleimani, SS Mandal - Cancer research, 2017 - AACR
In addition to mutations or aberrant expression in the protein-coding genes, mutations and
misregulation of noncoding RNAs, in particular long noncoding RNAs (lncRNA), appear to …

The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan

JJ Kotzin, SP Spencer, SJ McCright, DBU Kumar… - Nature, 2016 - nature.com
Neutrophils, eosinophils and 'classical'monocytes collectively account for about 70% of
human blood leukocytes and are among the shortest-lived cells in the body,. Precise …

[HTML][HTML] Long non-coding RNAs in Oral squamous cell carcinoma: biologic function, mechanisms and clinical implications

L Zhang, X Meng, X Zhu, D Yang, R Chen, Y Jiang… - Molecular cancer, 2019 - Springer
There is growing evidence that regions of the genome that cannot encode proteins play an
important role in diseases. These regions are usually transcribed into long non-coding …

[HTML][HTML] LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration

L Wang, Y Zhao, X Bao, X Zhu, YK Kwok, K Sun… - Cell research, 2015 - nature.com
Emerging studies document the roles of long non-coding RNAs (LncRNAs) in regulating
gene expression at chromatin level but relatively less is known how they regulate DNA …

Long noncoding RNAs: Lessons from genomic imprinting

C Kanduri - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2016 - Elsevier
Genomic imprinting has been a great resource for studying transcriptional and post-
transcriptional-based gene regulation by long noncoding RNAs (lncRNAs). In this article, I …

[HTML][HTML] A lncRNA from an inflammatory bowel disease risk locus maintains intestinal host-commensal homeostasis

H Ma, T Hu, W Tao, J Tong, Z Han… - Cell Research, 2023 - nature.com
Inflammatory bowel diseases (IBD) are known to have complex, genetically influenced
etiologies, involving dysfunctional interactions between the intestinal immune system and …