With recent advances in single-cell RNA sequencing, enormous transcriptome datasets
have been generated. These datasets have furthered our understanding of cellular …

Bacterial cells are widely used to produce value-added products due to their versatility, ease
of manipulation, and the abundance of genome engineering tools. However, the efficiency of …

Genetic and other variations frequently affect protein functions. Scientific articles can contain
confusing descriptions about which function or property is affected, and in many cases the …

Synthetic biology has grown exponentially in the last few years, with a variety of biological
applications. One of the emerging applications of synthetic biology is to exploit the link …

The growth and survival of an organism in a particular environment is highly depends on the
certain indispensable genes, termed as essential genes. Sulfate-reducing bacteria (SRB) …

Identifying relevant disease modules such as target cell types is a significant step for
studying diseases. High-throughput single-cell RNA-Seq (scRNA-seq) technologies have …

Geptop has performed effectively in the identification of prokaryotic essential genes since its
first release in 2013. It estimates gene essentiality for prokaryotes based on orthology and …

When a null mutation of a gene causes a complete developmental arrest, the gene is
typically considered essential for life. Yet, in most cases, null mutations have more subtle …

Gene essentiality is a genetic concept crucial for a comprehensive understanding of life and
evolution. In the last decade, many essential genes (EGs) have been determined using …

The identification and characterization of essential genes are central to our understanding of
the core biological functions in eukaryotic organisms, and has important implications for the …