Members of the nuclear receptor superfamily of ligand-dependent transcription factors carry
out vital cellular functions and are highly druggable therapeutic targets. Liver X receptors …

Retinoic acid (RA) signaling pathways regulate fundamental biological processes, such as
cell proliferation, development, differentiation, and apoptosis. Retinoid receptors (RARs and …

Acute myeloid leukemia (AML) is characterized by impaired differentiation and indefinite
proliferation of abnormal myeloid progenitors. Although differentiating agents were deemed …

Nuclear receptors (NRs) are a superfamily of ligand-activated transcription factors that act as
biological sensors and use a combination of mechanisms to modulate positively and …

Cholesterol is a vital lipid for cellular functions. It is necessary for membrane biogenesis, cell
proliferation, and differentiation. In addition to maintaining cell integrity and permeability …

Blastic plasmacytoid dendritic cell (PDC) neoplasm (BPDCN) is an aggressive
hematological malignancy with a poor prognosis that derives from PDCs. No consensus for …

Acute myeloid leukemia (AML), as the most common malignancy of the hematopoietic
system, poses challenges in treatment efficacy, relapse, and drug resistance. In this study …

Abstract LSD1 (Lysine Specific Demethylase1)/KDM1A (Lysine Demethylase 1A), a flavin
adenine dinucleotide (FAD)-dependent histone H3K4/K9 demethylase, sustains oncogenic …

Introduction: Retinoic acid X receptors play key roles in tumor cell proliferation,
differentiation, apoptosis and angiogenesis via transcriptional regulation. Bexarotene is a …

Introduction: The ligand-activated transcription factors, nuclear hormone receptors (NHRs),
remain unexplored in hematological malignancies except for retinoic acid receptor alpha …