Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also
in the activation, differentiation and effector function (s) of immune cells. In this review, we …

Myeloid-derived suppressor cells (MDSC) are a diverse population of immature myeloid
cells that have potent immune-suppressive activity. Studies in both mice and humans have …

Staphylococcus aureus is a leading cause of biofilm-associated prosthetic joint infection
(PJI), resulting in considerable disability and prolonged treatment. It is known that host …

Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells characterized by
their immunosuppressive functions. MDSCs expand during chronic and acute inflammatory …

Cancer cells employ a number of mechanisms to escape immunosurveillance and facilitate
tumour progression. The recent explosion of interest in immunotherapy, especially immune …

Epigenetic mechanisms, such as acetylation, methylation, and succinylation, play pivotal
roles in the regulation of multiple normal biological processes, including neuron regulation …

Simple Summary Immunotherapy has made a breakthrough in medical oncology with the
approval of several immune checkpoint inhibitors in multiple cancer types. Since only a …

Macrophages are polarized into functional classically activated and alternatively activated
(M2) phenotypes depending on their microenvironment, and these cells play an important …

Chronic immune activation and inflammation are unwanted consequences of many
pathological conditions, since they could lead to tissue damage and immune exhaustion …

The smallest histone deacetylase (HDAC) and the only class IV HDAC member, HDAC11, is
reported to regulate immune activation and tumorigenesis, yet its biochemical function is …