Irreversible inhibition of acetylcholinesterase (AChE) by organophosphates leads to many
failures in living organism and ultimately in death. Organophosphorus compounds …

New compounds containing thiazole and pyridinium moieties were designed and
synthesized. The potency of the synthesized compounds as selective inhibitors of …

Organophosphorus Compounds (OPCs) are used as pesticides to control pest, as chemical
weapons in military conflict and unfortunately in the terrorist attack. These compounds are …

The expeditious synthesis of an API building block, 2-cyanothiazole, from cyanogen gas and
a readily available dithiane is reported. A previously undisclosed partially saturated …

Many heterocyclic compounds containing nitrogen atom are used in drug development.
Thiazole is one of the most important heterocyclic compounds in drug design, which …

Quorum sensing is a communication system among bacteria to sense the proper time to
express their virulence factors. Quorum sensing inhibition is a therapeutic strategy to block …

Background: Physicochemical properties play important role in fundamental issues like
absorption and distribution of pharmaceuticals to the target tissue. This is particularly …

New thiazole‐clubbed piperazine derivatives were designed, synthesized, evaluated for
their inhibitory capabilities against human acetylcholinesterase and butyrylcholinesterase …

Acetylcholinesterase (AChE) is well-known enzyme studied in many fields of research, eg in
Alzheimer's disease, Parkinson's disease, or in eco-toxicology as a biological marker. Many …

A series of mono pyridinium oximes linked with arenylacetamides as side chains were
synthesized and their in vitro reactivation potential was evaluated against human …