Abstract Cellular binding-proteins (BP), including CRBP1, CRBP2, CRABP1, CRABP2, and
FABP5, shepherd the poorly aqueous soluble retinoids during uptake, metabolism and …

All-trans retinoic acid (ATRA), an active metabolite of vitamin A, plays important roles in cell
proliferation, cell differentiation, apoptosis, and embryonic development. The effects of ATRA …

Abstract Methyltransferase-like 3 (METTL3) is the catalytic subunit of the N 6-adenosine
methyltransferase complex responsible for N 6-methyladenosine (m6A) modification of …

Although the use of oral administration of pharmacological all-trans retinoic acid (ATRA)
concentration in acute promyelocytic leukaemia (APL) patients was approved for over 20 …

Organotypic tissue slice culture is established from animal or patient tissues and cultivated
in an in vitro ecosystem. This technique has made countless contributions to anticancer drug …

For decades, retinoids and their synthetic derivatives have been well established anticancer
treatments due to their ability to regulate cell growth and induce cell differentiation and …

Background Annexin A2 is increased in serous ovarian cancer and plays an essential role in
ovarian cancer invasion and metastasis. In combination with S100A10, annexin A2 plays an …

Background Gastric-cancer is a heterogeneous type of neoplastic disease and it lacks
appropriate therapeutic options. There is an urgent need for the development of innovative …

Breast cancer is the most common malignancy in women, with metastases being the cause
of death in 98%. In previous works we have demonstrated that retinoic acid (RA), the main …

Although extensive research progress has been made in breast cancer in recent years, yet
the morbidity and mortality rates of breast cancer are rising, making it the major disease that …