Engineered bacterial membrane vesicles are promising carriers for vaccine design and tumor immunotherapy

Q Long, P Zheng, X Zheng, W Li, L Hua, Z Yang… - Advanced drug delivery …, 2022 - Elsevier
Bacterial membrane vesicles (BMVs) have emerged as novel and promising platforms for
the development of vaccines and immunotherapeutic strategies against infectious and …

Outer membrane vesicles as platform vaccine technology

L Van Der Pol, M Stork, P van der Ley - Biotechnology journal, 2015 - Wiley Online Library
Outer membrane vesicles (OMVs) are released spontaneously during growth by many Gram‐
negative bacteria. They present a range of surface antigens in a native conformation and …

Modern subunit vaccines: development, components, and research opportunities

PM Moyle, I Toth - ChemMedChem, 2013 - Wiley Online Library
Traditional vaccines, based on the administration of killed or attenuated microorganisms,
have proven to be among the most effective methods for disease prevention. Safety issues …

[HTML][HTML] Bioengineering bacterial outer membrane vesicles as vaccine platform

MJH Gerritzen, DE Martens, RH Wijffels… - Biotechnology …, 2017 - Elsevier
Outer membrane vesicles (OMVs) are naturally non-replicating, highly immunogenic
spherical nanoparticles derived from Gram-negative bacteria. OMVs from pathogenic …

Outer membrane vesicles for vaccination and targeted drug delivery

S Wang, J Gao, Z Wang - Wiley Interdisciplinary Reviews …, 2019 - Wiley Online Library
Extracellular vesicles (EVs) are cell membrane‐derived compartments that spontaneously
secrete from a wide range of cells and tissues. EVs have shown to be the carriers in …

Bacterial membrane vesicles: physiological roles, infection immunology, and applications

Y Gan, G Zhao, Z Wang, X Zhang, MX Wu… - Advanced …, 2023 - Wiley Online Library
Bacterial or fungal membrane vesicles, traditionally considered as microbial metabolic
wastes, are secreted mainly from the outer membrane or cell membrane of microorganisms …

Advances and opportunities in nanoparticle‐and nanomaterial‐based vaccines against bacterial infections

LCW Lin, S Chattopadhyay, JC Lin… - Advanced healthcare …, 2018 - Wiley Online Library
As the dawn of the postantibiotic era we approach, antibacterial vaccines are becoming
increasingly important for managing bacterial infection and reducing the need for antibiotics …

Biotechnology approaches to produce potent, self-adjuvanting antigen-adjuvant fusion protein subunit vaccines

PM Moyle - Biotechnology advances, 2017 - Elsevier
Traditional vaccination approaches (eg live attenuated or killed microorganisms) are among
the most effective means to prevent the spread of infectious diseases. These approaches …

Designs of antigen structure and composition for improved protein-based vaccine efficacy

K Saylor, F Gillam, T Lohneis, C Zhang - Frontiers in immunology, 2020 - frontiersin.org
Today, vaccinologists have come to understand that the hallmark of any protective immune
response is the antigen. However, it is not the whole antigen that dictates the immune …

Targeting TLR2 for vaccine development

AP Basto, A Leitão - Journal of immunology research, 2014 - Wiley Online Library
Novel and more effective immunization strategies against many animal diseases may profit
from the current knowledge on the modulation of specific immunity through stimulation of …