Role of microRNAs in diabetes and its cardiovascular complications

S Shantikumar, A Caporali… - Cardiovascular …, 2012 - academic.oup.com
Diabetes is the most common metabolic disorder and is recognized as one of the most
important health threats of our time. MicroRNAs (miRNAs) are a novel group of non-coding …

Therapeutic angiogenesis and vasculogenesis for tissue regeneration

P Madeddu - Cardiovascular Genomics, 2005 - Springer
Therapeutic angiogenesis/vasculogenesis represents a new approach to treating patients
with ischemic disease not curable with conventional treatment. Manipulation of the …

[HTML][HTML] TNF-α mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term histopathological alterations

AM Joussen, S Doehmen, ML Le, K Koizumi… - Molecular …, 2009 - ncbi.nlm.nih.gov
Purpose The pathophysiology of diabetic retinopathy involves leukocyte adhesion to retinal
vasculature, early blood-retinal barrier breakdown, capillary nonperfusion, and endothelial …

Human CD133+ Progenitor Cells Promote the Healing of Diabetic Ischemic Ulcers by Paracrine Stimulation of Angiogenesis and Activation of Wnt Signaling

LS Barcelos, C Duplaa, N Kränkel, G Graiani… - Circulation …, 2009 - Am Heart Assoc
We evaluated the healing potential of human fetal aorta-derived CD133+ progenitor cells
and their conditioned medium (CD133+ CCM) in a new model of ischemic diabetic ulcer …

Diabetes and vessel wall remodelling: from mechanistic insights to regenerative therapies

G Spinetti, N Kraenkel, C Emanueli… - Cardiovascular …, 2008 - academic.oup.com
Over the past two decades, extensive research has focused on arterial remodelling in both
physiological and pathological ageing. The concept now describes the growth as well as the …

Effects of experimental type 1 diabetes and exercise training on angiogenic gene expression and capillarization in skeletal muscle

R Kivelä, M Silvennoinen, AM Touvra… - The FASEB …, 2006 - Wiley Online Library
Diabetes alters microvascular structure and function and is a major risk factor for
cardiovascular diseases. In diabetic skeletal muscle, impaired angiogenesis and reduced …

De Novo Lipogenesis Maintains Vascular Homeostasis through Endothelial Nitric-oxide Synthase (eNOS) Palmitoylation*♦

X Wei, JG Schneider, SM Shenouda, A Lee… - Journal of Biological …, 2011 - ASBMB
Endothelial dysfunction leads to lethal vascular complications in diabetes and related
metabolic disorders. Here, we demonstrate that de novo lipogenesis, an insulin-dependent …

Daily rhythms of TNFα expression and food intake regulate synchrony of Plasmodium stages with the host circadian cycle

IC Hirako, PA Assis, NS Hojo-Souza, G Reed… - Cell host & …, 2018 - cell.com
The Plasmodium cell cycle, wherein millions of parasites differentiate and proliferate, occurs
in synchrony with the vertebrate host's circadian cycle. The underlying mechanisms are …

Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and inhibition of …

S Gadau, C Emanueli, S Van Linthout, G Graiani… - Diabetologia, 2006 - Springer
Aims/hypothesis Benfotiamine, a vitamin B1 analogue, reportedly prevents diabetic
microangiopathy. The aim of this study was to evaluate whether benfotiamine is of benefit in …

Efficient cutaneous wound healing using bixin‐loaded PCL nanofibers in diabetic mice

AD Pinzón‐García, P Cassini‐Vieira… - … Research Part B …, 2017 - Wiley Online Library
The present work demonstrated an efficient cutaneous wound healing using Bixin‐loaded
polycaprolactone (PCL) nanofibers as a controlled delivery system. The influence of Bixin …