Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

JY Hansen, G Shafiei, RD Markello, K Smart… - Nature …, 2022 - nature.com
Neurotransmitter receptors support the propagation of signals in the human brain. How
receptor systems are situated within macro-scale neuroanatomy and how they shape …

Local molecular and global connectomic contributions to cross-disorder cortical abnormalities

JY Hansen, G Shafiei, JW Vogel, K Smart… - Nature …, 2022 - nature.com
Numerous brain disorders demonstrate structural brain abnormalities, which are thought to
arise from molecular perturbations or connectome miswiring. The unique and shared …

Integrating brainstem and cortical functional architectures

JY Hansen, S Cauzzo, K Singh… - Nature …, 2024 - nature.com
The brainstem is a fundamental component of the central nervous system, yet it is typically
excluded from in vivo human brain mapping efforts, precluding a complete understanding of …

Contributions of network structure, chemoarchitecture and diagnostic categories to transitions between cognitive topographies

AI Luppi, SP Singleton, JY Hansen… - Nature Biomedical …, 2024 - nature.com
The mechanisms linking the brain's network structure to cognitively relevant activation
patterns remain largely unknown. Here, by leveraging principles of network control, we show …

Quantitative positron emission tomography in brain research

K Heurling, A Leuzy, M Jonasson, A Frick, ER Zimmer… - Brain research, 2017 - Elsevier
The application of positron emission tomography (PET) in brain research has increased
substantially during the past 20 years, and is still growing. PET provides a unique insight …

Cerebral chemoarchitecture shares organizational traits with brain structure and function

B Hänisch, JY Hansen, BC Bernhardt, SB Eickhoff… - ELife, 2023 - elifesciences.org
Chemoarchitecture, the heterogeneous distribution of neurotransmitter transporter and
receptor molecules, is a relevant component of structure–function relationships in the human …

[HTML][HTML] Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain

JY Hansen, RD Markello, L Tuominen, M Nørgaard… - NeuroImage, 2022 - Elsevier
Neurotransmitter receptors modulate signaling between neurons. Thus, neurotransmitter
receptors and transporters play a key role in shaping brain function. Due to the lack of …

New trends and current status of positron-emission tomography and single-photon-emission computerized tomography radioligands for neuronal serotonin receptors …

PP Hazari, A Pandey, S Chaturvedi… - Bioconjugate …, 2017 - ACS Publications
The critical role of serotonin (5-hydroxytryptamine; 5-HT) and its receptors (5-HTRs) in the
pathophysiology of diverse neuropsychiatric and neurodegenerative disorders render them …

OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding

C Pittenger, TG Adams Jr, JD Gallezot… - Journal of affective …, 2016 - Elsevier
Obsessive-compulsive disorder (OCD) is characterized by impaired sensorimotor gating, as
measured using prepulse inhibition (PPI). This effect may be related to abnormalities in the …

Individualized gray matter morphological abnormalities uncover two robust transdiagnostic biotypes

K Fang, Y Hou, L Niu, S Han, W Zhang - Journal of Affective Disorders, 2024 - Elsevier
Psychiatric disorders exhibit a shared neuropathology, yet the diverse presentations among
patients necessitate the identification of transdiagnostic subtypes to enhance diagnostic and …