In healthy individuals, the majority of cortisol secretion occurs within several hours
surrounding morning awakening. A highly studied component of this secretory period is the …

The glucocorticoid receptor α (GRα) is a member of the nuclear receptor superfamily and
functions as a glucocorticoid (GC)-responsive transcription factor. GR can halt inflammation …

Disrupted circadian activity is associated with many neuropsychiatric disorders. A major
coordinator of circadian biological systems is adrenal glucocorticoid secretion which exhibits …

Background Primary adrenal insufficiency (PAI) mortality and morbidity remain unacceptably
high, possibly arising as glucocorticoid replacement does not replicate natural physiology. A …

Here we demonstrate, in rodents, how the timing of feeding behaviour becomes disordered
when circulating glucocorticoid rhythms are dissociated from lighting cues; a phenomenon …

Liver fibrosis is a determinant-stage process of many chronic liver diseases and affected
over 7.9 billion populations worldwide with increasing demands of ideal therapeutic agents …

Glucocorticoids are essential hormones produced by the adrenal cortex with prominent
circadian rhythmicity and in times of stress. Glucocorticoids maintain liver homeostasis …

Despite best practice replacement therapy with corticosteroids, patients with adrenal
insufficiency report diminished quality of life and face increased mortality and morbidity …

Over 50% of depressed patients show hyperactivity of the hypothalamic–pituitary–adrenal
(HPA) axis. Conventional therapy takes weeks to months to improve symptoms. Ketamine …

Adverse early life experiences are strongly associated with reduced cognitive function
throughout life. The link is strong in many human studies, but these do not enable assigning …