Trimethoprim-Sulfamethoxazole (Bactrim) Dose Optimization in Pneumocystis jirovecii Pneumonia (PCP) Management: A Systematic Review

A Haseeb, MAS Abourehab, WA Almalki… - International Journal of …, 2022 - mdpi.com
(1) Background: Pneumocystis jirovecii pneumonia (PCP) has a substantial impact on the
morbidity and mortality of patients, especially those with autoimmune disorders, thus …

Oral fluoroquinolone or trimethoprim-sulfamethoxazole vs ß-lactams as step-down therapy for Enterobacteriaceae bacteremia: systematic review and meta-analysis

C Punjabi, V Tien, L Meng, S Deresinski… - Open Forum …, 2019 - academic.oup.com
Background Using published data, we sought to compare outcomes in patients transitioned
to either oral fluoroquinolones (FQs) or trimethoprim-sulfamethoxazole (TMP-SMX) vs ß …

[HTML][HTML] Antimicrobial treatment and prophylaxis of plague: recommendations for naturally acquired infections and bioterrorism response

CA Nelson - MMWR. Recommendations and Reports, 2021 - cdc.gov
This report provides CDC recommendations to US health care providers regarding
treatment, pre-exposure prophylaxis, and postexposure prophylaxis of plague. Yersinia …

Developmental pharmacokinetics of antibiotics used in neonatal ICU: focus on preterm infants

OI Butranova, EA Ushkalova, SK Zyryanov… - Biomedicines, 2023 - mdpi.com
Neonatal Infections are among the most common reasons for admission to the intensive
care unit. Neonatal sepsis (NS) significantly contributes to mortality rates. Empiric antibiotic …

Development and evaluation of a virtual population of children with obesity for physiologically based pharmacokinetic modeling

JG Gerhart, FO Carreño, AN Edginton, J Sinha… - Clinical …, 2022 - Springer
Abstract Background and Objective While one in five children in the USA are now obese,
and more than three-quarters receive at least one drug during childhood, there is limited …

Challenges for global antibiotic regimen planning and establishing antimicrobial resistance targets: implications for the WHO Essential Medicines List and AWaRe …

N Reza, A Gerada, KE Stott, A Howard… - Clinical Microbiology …, 2024 - Am Soc Microbiol
SUMMARY The World Health Organisation's 2022 AWaRe Book provides guidance for the
use of 39 antibiotics to treat 35 infections in primary healthcare and hospital facilities. We …

Oral Antibiotics for Bacteremia and Infective Endocarditis: Current Evidence and Future Perspectives

G Eleftheriotis, M Marangos, M Lagadinou, S Bhagani… - Microorganisms, 2023 - mdpi.com
Bacteremia and endocarditis are two clinical syndromes that, for decades, were managed
exclusively with parenteral antimicrobials, irrespective of a given patient's clinical condition …

Treatment of childhood Brucellosis: A systematic review

EL Galvão, KM Souza, MG de Freitas… - The Pediatric …, 2024 - journals.lww.com
Background: Proper treatment for brucellosis is crucial to eradicate the infection and prevent
complications, but there is a notable gap in evidence for pediatric treatment. This study aims …

First international quality control programme for laboratories measuring antimicrobial drugs to support dose individualization in critically ill patients

E Wallenburg, RJ Brüggemann, K Asouit… - Journal of …, 2021 - academic.oup.com
Objectives International quality control (proficiency testing) programmes are instituted to
safeguard the analytical performance of laboratories and to aid these laboratories in …

Utilization of data below the analytical limit of quantitation in pharmacokinetic analysis and modeling: promoting interdisciplinary debate

M Hecht, R Veigure, L Couchman, CI S Barker… - Bioanalysis, 2018 - Taylor & Francis
Traditionally, bioanalytical laboratories do not report actual concentrations for samples with
results below the LOQ (BLQ) in pharmacokinetic studies. BLQ values are outside the method …