Polymersome-based protein drug delivery–quo vadis?

MG Gouveia, JP Wesseler, J Ramaekers… - Chemical Society …, 2023 - pubs.rsc.org
Protein-based therapeutics are an attractive alternative to established therapeutic
approaches and represent one of the fastest growing families of drugs. While many of these …

Liposomes for oral delivery of protein and peptide-based therapeutics: Challenges, formulation strategies, and advances

A Jash, A Ubeyitogullari, SSH Rizvi - Journal of Materials Chemistry B, 2021 - pubs.rsc.org
Throughout the past decade, there has been a rapid growth in the development of
protein/peptide-based therapeutics. These therapeutics have found widespread applications …

Effect of formulation method, lipid composition, and PEGylation on vesicle lamellarity: a small-angle neutron scattering study

V Nele, MN Holme, U Kauscher, MR Thomas… - Langmuir, 2019 - ACS Publications
Liposomes are well-established systems for drug delivery and biosensing applications. The
design of a liposomal carrier requires careful choice of lipid composition and formulation …

Phase‐Separated Lipid‐Based Nanoparticles: Selective Behavior at the Nano‐Bio Interface

P Papadopoulou, R van der Pol… - Advanced …, 2024 - Wiley Online Library
The membrane‐protein interface on lipid‐based nanoparticles influences their in vivo
behavior. Better understanding may evolve current drug delivery methods toward effective …

Coupling lipid nanoparticle structure and automated single‐particle composition analysis to design phospholipase‐responsive nanocarriers

HMG Barriga, IJ Pence, MN Holme… - Advanced …, 2022 - Wiley Online Library
Lipid nanoparticles (LNPs) are versatile structures with tunable physicochemical properties
that are ideally suited as a platform for vaccine delivery and RNA therapeutics. A key barrier …

Structural basis for the unique molecular properties of broad-range phospholipase C from Listeria monocytogenes

N Petrišič, M Adamek, A Kežar, SB Hočevar… - Nature …, 2023 - nature.com
Listeriosis is one of the most serious foodborne diseases caused by the intracellular
bacterium Listeria monocytogenes. Its two major virulence factors, broad-range …

Local accumulation of diacylglycerol alters membrane properties nonlinearly due to its transbilayer activity

P Campomanes, V Zoni, S Vanni - Communications Chemistry, 2019 - nature.com
Diacylglycerols (DAGs) are bioactive lipids that are ubiquitously present at low
concentrations in cellular membranes. Upon the activation of lipid remodeling enzymes such …

Phase‐Separated Liposomes Hijack Endogenous Lipoprotein Transport and Metabolism Pathways to Target Subsets of Endothelial Cells In Vivo

G Arias‐Alpizar, P Papadopoulou… - Advanced …, 2023 - Wiley Online Library
Plasma lipid transport and metabolism are essential to ensure correct cellular function
throughout the body. Dynamically regulated in time and space, the well‐characterized …

[HTML][HTML] The molecular mechanisms of listeriolysin O-induced lipid membrane damage

N Petrišič, M Kozorog, S Aden, M Podobnik… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Listeria monocytogenes is an intracellular food-borne pathogen that causes listeriosis, a
severe and potentially life-threatening disease. Listeria uses a number of virulence factors to …

Recent advances in oral peptide or protein-based drug liposomes

J Cui, Z Wen, W Zhang, W Wu - Pharmaceuticals, 2022 - mdpi.com
The high physiology and low toxicity of therapeutic peptides and proteins have made them a
hot spot for drug development in recent years. However, their poor oral bioavailability and …