Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging
and in chronic kidney disease (CKD), regardless of cause. CKD and renal fibrosis affect half …

Tissue hypoxia has been proposed as an important factor in the pathophysiology of both
chronic kidney disease (CKD) and acute kidney injury (AKI), initiating and propagating a …

Unilateral ischemia-reperfusion (UIR) injury leads to progressive renal atrophy and
tubulointerstitial fibrosis (TIF) and is commonly used to investigate the pathogenesis of the …

Damage to the kidney substantially reduces life expectancy. Renal tissue hypoperfusion and
hypoxia are key elements in the pathophysiology of acute kidney injury and its progression …

The extracellular matrix component collagen is widely expressed in human tissues and
participates in various cellular biological processes. The collagen amount generally remains …

Key points Our understanding of the mechanisms underlying the role of hypoxia in the
initiation and progression of renal disease remains rudimentary. We have developed a …

Aim Kidney diseases constitute a major health challenge, which requires noninvasive
imaging to complement conventional approaches to diagnosis and monitoring. Several …

Renal tissue hypoperfusion and hypoxia are early key elements in the pathophysiology of
acute kidney injury of various origins, and may also promote progression from acute injury to …

Renal pathologies often manifest as alterations in kidney size, providing a valuable avenue
for employing dynamic parametric MRI as a means to derive kidney size measurements for …

Background Renal hypoxia, implicated as crucial factor in onset and progression of chronic
kidney disease, may be attributed to reduced nitric oxide because nitric oxide dilates …